Degrader discovery and design at TPD Summit 2026

Oct 26–29, 2026 Boston, MA ~300 attendees Website

45 organizations at TPD Summit 2026 present work in degrader discovery & design: 22 drug developers, 13 technology and service providers and 10 academic, government and non-profit bodies. Between them they bring 57 presentations to the program. Most represented: Protai (2 on the program), Astellas (2 on the program), AstraZeneca (2 on the program). As of Oct 20, 2026.

All 96 organizations at TPD Summit 2026 →

Format
Top represented
Showing 1–14 of 45 organizations
OrganizationTPD Summit 2026 Attendance
Biotech
Combines proteomics and AI to discover drug targets, biomarkers and degraders.
Panel
Tue Oct 27
3:10pm
Harnessing Rational Design and Structural Insights to Develop Induced Proximity Molecules with Enhanced Translational Potential
Track B: Pre-Clinical Development · with Concarlo Therapeutics, Biogen, Lyterian Therapeutics +1 more
Degrader discovery & design
Talk
Wed Oct 28
11:30am
Proteomics & AI Platform Maps Degrader-Induced Ternary Complex Diversity to Enable Rational Degrader Design
Track A: Discovery
AI & computational designScreening, assays & proteomics
Panel
Thu Oct 29
10:00am
Harnessing AI & Computational Modelling to Optimize Design, Specificity & Efficacy of Induced Proximity Molecules to Support the Development of Tolerable, Selective Therapies
Latest Tools & Technologies Track · with Orionis Biosciences, Eli Lilly, Genentech
AI & computational design
Astellas
Tokyo, Japan
◇Industry Partner
Large pharmaIndustry Partner
Japanese pharmaceutical company with a targeted protein degradation program, including the KRAS G12D degrader setidegrasib.
Talk
Tue Oct 27
2:00pm
Clinical Proof of Concept of Setidegrasib (ASP3082)
Track C: Translational & Clinical Development
Talk
Wed Oct 28
3:00pm
Optimizing Novel Heterobifunctional Degraders – An Update
Track A: Discovery
AstraZeneca
Cambridge, UK
Large pharma
Global pharmaceutical company developing medicines in oncology, cardiovascular, renal, respiratory, immunology and rare diseases.
Talk
Wed Oct 28
2:30pm
Linking Molecular Glue Binding Kinetics to Functional Performance Through Quantitative Modeling
Track A: Discovery
AI & computational design
Talk
Thu Oct 29
9:30am
Developing AURKB PROTACs as a Novel Payload Class for Next-Generation Degrader Antibody Conjugates (DACs)
Future of Induced Proximity Track
Degrader conjugates & tissue targeting
Biotech
Clinical-stage biotech targeting the chromatin regulatory system with small molecules and protein degraders for cancer.
Panel
Tue Oct 27
9:00am
Navigating the Evolving Induced Proximity Landscape: Trends, Opportunities & Global Impact
Plenary · with Nurix Therapeutics, Stablix, C4 Therapeutics +1 more
Investment, partnering & strategy
Talk
Thu Oct 29
10:30am
Proximity by Design: Harnessing Induced Proximity for Challenging Targets
Future of Induced Proximity Track
Degrader discovery & design
Yale University
New Haven, CT
Academic & research
Private research university in New Haven, Connecticut, with a school of medicine.
Talk
Mon Oct 26
1:45pm
Enhancing Inhibition via Chemically Induced Proximity: A RIPTAC Targeting BCL6 & BET Proteins
Research Breakthroughs Day
Induced proximity beyond degradation
Panel
Mon Oct 26
2:15pm
Shaping the Future of Induced Proximity Research to Drive Innovative Discovery & Support the Development of Pipeline-Ready Candidates
Research Breakthroughs Day · with Janus Drug Discovery Consulting, Broad Institute, Albert Einstein College of Medicine +1 more
Degrader discovery & design
Biotech
Develops cancer therapeutics built on p27 biology, including molecular glue stabilizers, for drug-resistant cancers.
Panel
Tue Oct 27
3:10pm
Harnessing Rational Design and Structural Insights to Develop Induced Proximity Molecules with Enhanced Translational Potential
Track B: Pre-Clinical Development · with Protai, Biogen, Lyterian Therapeutics +1 more
Degrader discovery & design
Talk
Thu Oct 29
12:15pm
Locktacs for Intrinsically Disordered Proteins: First-in-Class p27 Molecular Glue Stabilizers
Future of Induced Proximity Track
Induced proximity beyond degradation
Investors & other services
Drug discovery consultancy advising biotech management teams and investors.
Chair
Mon Oct 26
8:50am
Part of Deciphering the Molecular Basis of Induced Proximity to Enable Predictive & Mechanism-Guided Drug Discovery
Chair’s Opening Remarks
Research Breakthroughs Day
Degrader discovery & design
Panel
Mon Oct 26
2:15pm
Shaping the Future of Induced Proximity Research to Drive Innovative Discovery & Support the Development of Pipeline-Ready Candidates
Research Breakthroughs Day · with Broad Institute, Yale University, Albert Einstein College of Medicine +1 more
Degrader discovery & design
Chair
Mon Oct 26
4:15pm
Part of Applying Next-Generation Technologies & Screening Platforms to Drive Innovation & Discovery Across Induced Proximity Mechanisms
Chair’s Closing Remarks
Research Breakthroughs Day
Screening, assays & proteomics
Academic & research
Medical school and biomedical research institution in the Bronx, New York.
Talk
Mon Oct 26
9:30am
αC-Helix–Proximal Allostery as a Platform for Selective Kinase Modulation & Complex Degradation
Research Breakthroughs Day
Degrader discovery & designInduced proximity beyond degradation
Panel
Mon Oct 26
2:15pm
Shaping the Future of Induced Proximity Research to Drive Innovative Discovery & Support the Development of Pipeline-Ready Candidates
Research Breakthroughs Day · with Janus Drug Discovery Consulting, Broad Institute, Yale University +1 more
Degrader discovery & design
Broad Institute
Cambridge, MA
Academic & research
Biomedical and genomic research institute in Cambridge, Massachusetts, founded by MIT and Harvard.
Panel
Mon Oct 26
2:15pm
Shaping the Future of Induced Proximity Research to Drive Innovative Discovery & Support the Development of Pipeline-Ready Candidates
Research Breakthroughs Day · with Janus Drug Discovery Consulting, Yale University, Albert Einstein College of Medicine +1 more
Degrader discovery & design
Talk
Mon Oct 26
3:45pm
Diverse Mechanisms of Small Molecule Induced Protein Degradation
Research Breakthroughs Day
Degrader discovery & design
Biotech
Indiana biotech discovering small-molecule degraders of proteins that cause neurodegenerative disease, starting from an APP degrader.
Talk
Wed Oct 28
4:15pm
Molecular Glue Degrader–Induced Co-Degradation of Mutant KRAS & CRAF Drives In Vivo Responses
Plenary
Degrader discovery & design
Talk
Thu Oct 29
2:15pm
Molecular Glue Degraders Enhance CAPRIN1-Dependent Lysosomal Degradation of APP & Reduce Amyloid in Alzheimer’s Disease
Future of Induced Proximity Track
Degrader discovery & design
Academic & research
Public research university in Atlanta, Georgia.
Talk
Mon Oct 26
3:15pm
GlueFinder: A Data-Driven Framework for the Rational Discovery of Molecular Glues
Research Breakthroughs Day
AI & computational designDegrader discovery & design
Panel
Tue Oct 27
3:10pm
Harnessing Rational Design and Structural Insights to Develop Induced Proximity Molecules with Enhanced Translational Potential
Track B: Pre-Clinical Development · with Concarlo Therapeutics, Protai, Biogen +1 more
Degrader discovery & design
Biotech
Biotech developing targeted protein degraders.
Chair
Thu Oct 29
8:20am
Part of Developing Next-Generation Degraders to Achieve Tissue-Specific Protein Degradation & Enable Development of Clinically Impactful Therapies
Chair’s Opening Remarks
Future of Induced Proximity Track
Degrader conjugates & tissue targeting
Chair
Thu Oct 29
2:45pm
Part of Expanding the Therapeutic Horizon of Induced Proximity Modalities for Immunology, Neuroscience & Beyond to Bring Effective Treatment Options to More Patients
Chair’s Closing Remarks
Future of Induced Proximity Track
Degrader discovery & design
Biotech
Develops targeted protein degraders that use a new E3 ligase, aiming to reduce hematologic toxicity.
Talk
Tue Oct 27
12:30pm
A Novel TPD Platform Leveraging a New E3 Ligase to Minimize Hematologic Toxicity
Track A: Discovery
Panel
Wed Oct 28
2:00pm
Translating Early Clinical Signals into Strategies for Maximizing Efficacy & Safety of Induced Proximity Therapeutics
Track C: Translational & Clinical Development · with PAQ Therapeutics, Takeda
UC Irvine
Irvine, CA
Academic & research
Public research university in Irvine, California.
Talk
Mon Oct 26
10:00am
Methylarginine Targeting Chimeras for Lysosomal Degradation of Intracellular Proteins
Research Breakthroughs Day
Degrader discovery & design
Panel
Mon Oct 26
2:15pm
Shaping the Future of Induced Proximity Research to Drive Innovative Discovery & Support the Development of Pipeline-Ready Candidates
Research Breakthroughs Day · with Janus Drug Discovery Consulting, Broad Institute, Yale University +1 more
Degrader discovery & design

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