GG
GeneT Gene Therapy Center of Excellence at ESGCT 2026
Oct 27–30, 2026 Hamburg, Germany ~2.5k attendees Website
GeneT Gene Therapy Center of Excellence brings 7 presentations to ESGCT 2026 in Hamburg. Its work centres on gene therapy for inherited ataxias, with several strands aimed at silencing the mutant ataxin-3 gene behind Machado-Joseph disease. Other work covers building gene therapy capacity in East Africa and communicating the field to the public.
| Organization | ESGCT 2026 Attendance |
|---|---|
GG GeneT Gene Therapy Center of Excellence Coimbra, Portugal | |
Portugal's gene therapy research centre at the University of Coimbra, covering research, clinical trials and production for rare and untreatable diseases. | Poster Wed Oct 28 1:30pm–3:30pm From Awareness to Readiness: CAPACITY Strengthening for Gene Therapy in East Africa Poster Thu Oct 29 2:00pm–4:00pm Adeno-associated virus-mediated miR-128 delivery reduces ataxin-3 aggregation, partially rescues the cerebellar transcriptomic profile, and improves motor function in transgenic Machado–Joseph disease mice Poster Thu Oct 29 2:00pm–4:00pm Direct glial reprogramming in combination with mutant ataxin-3 silencing to treat Machado-Joseph Disease Poster Thu Oct 29 2:00pm–4:00pm Early systemic CYP46A1 gene therapy enhances therapeutic benefit in a mouse model of Spinocerebellar Ataxia Type 3 Poster Thu Oct 29 2:00pm–4:00pm GenExpress: a co-created, immersive, human-sized game for gene therapy communication Poster Thu Oct 29 2:00pm–4:00pm Multiplex CRISPRa-mediated activation of neuroprotective pathways rescues Machado–Joseph disease Talk Fri Oct 30 12:15pm–1:00pm Cross-species validation of allele-specific silencing for Spinocerebellar Ataxia type 3 RNA and oligonucleotide therapiesRare and inherited disease |
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