ASHG 2026 · Tier 1 Academic

Case Western Reserve University at ASHG 2026

Cleveland, Ohio

Case Western Reserve University at ASHG 2026 in Montréal: 19 presentations (16 posters, 2 featured symposia, 1 plenary); 6 research groups.

19
presentations on the program
6
research groups identified
2
sessions invited to or moderated

Explore everyone at ASHG 2026 →

OrganizationASHG 2026 Attendance
Case Western Reserve University
Cleveland, Ohio
6 PhD Students · 3 Postdocs · 2 Faculty · 2 PIs
Cleveland Institute for Computational Biologyicompbio.net/people/faculty/dana-c-crawford
Dry lab~12 people
Applies computational methods to electronic health records, biorepositories and large, diverse datasets. Translates findings into diagnosis, prognosis, treatment and prevention.
Funded by NHGRI
NHGRI, PAGE I study · active
“site of the larger NHGRI-funded PAGE I study”
Source: lab pages
6 platforms and techniques
Analyzes
Electronic health records, EHR-linked biorepositories
Techniques
Electronic phenotyping, GWAS, Pleiotropy analysis, Pharmacogenomics
Source: lab pages
No openings posted
Poster
Wed Oct 21
2:30 pm
APOL1 haplotype characterization leveraging whole genome short read sequencing in a general population from the All of Us Research Program
Statistical Genetics and Genetic Epidemiology
Collaborators: The Jackson Laboratory for Genomic Medicine, Cleveland Clinic +1 more
Complex diseasesGenetic epidemiologyPopulation genetics
Poster
Wed Oct 21
2:30 pm
Evaluation of genome-wide meta-imputation with ancestry-matched and structural variant reference panels for Alzheimer's disease cohorts
Statistical Genetics and Genetic Epidemiology
Collaborators: University of Miami, University of Pennsylvania +11 more
Alzheimer’s diseaseBioinformaticsComputational tools
Poster
Wed Oct 21
2:30 pm
Evaluating sequence-to-function deep learning models for ancestry-stratified regulatory variant effect prediction using multi-ancestry blood eQTLs
Artificial Intelligence and Machine Learning
Collaborators: University of Miami
Artificial intelligenceExpression quantitative trait lociPopulation geneticsGenetic variation
Symposium
Fri Oct 23
8:20 am
Two species, one disease: Host-pathogen coevolution in infectious diseases
Host-Pathogen Coevolution: Shaping Genetic Diversity and Disease Resistance
Haines Labeaglep.case.edu/haineslab_web
Dry lab~23 people
Develops statistical genetics methods for GWAS, whole-exome and whole-genome DNA sequencing, EHR and genomic data. Applies them to Alzheimer’s disease and age-related macular degeneration.
78 papers since 2024
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
JAMA Neurology, 2025
Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer’s disease
Cell Reports Medicine, 2024
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease
Annals of Neurology, 2024
Source: OpenAlex author A5020266650
Funded by NIH, NIH
NIH, Community outreach and recruitment among African American families · active
“Current NIH-funded work in the Cleveland area includes outreach and recruitment among families and individuals with African American ancestry.”
NIH, Alzheimer’s Disease Sequencing Project data analysis · active
“an ongoing NIH grant supporting data analysis for the Alzheimer’s Disease Sequencing Project led by Drs. Haines and Bush”
Source: lab pages
10 platforms and techniques
Analyzes
GWAS, Whole-exome DNA sequencing, Whole-genome DNA sequencing, Illumina HumanCoreExome chip, Custom capture sequencing
Techniques
Statistical genetic analysis, Genome-wide association analysis, Rare and common variant analysis, Family-based genetic studies, Longitudinal cognitive and clinical phenotyping
Source: lab pages
No openings posted
Poster
Wed Oct 21
2:30 pm
Multi-ethnic eQTL Investigation Identifies Novel Risk Loci for Age-related Macular Degeneration
Complex Traits and Polygenic Disorders
Collaborators: Jerusalem College of Technology
BioinformaticsExpression quantitative trait lociGenome-wide association studyImmune system
Poster
Fri Oct 23
2:30 pm
The Collaborative Amish Aging and Memory Project (CAAMP): A Resource for the Study of Age-Related Traits and Cognitive Function
Complex Traits and Polygenic Disorders
Collaborators: University of Miami
Alzheimer’s diseaseIdentification of disease genesComplex diseasesGenetic epidemiology
Poster
Fri Oct 23
2:30 pm
Rare structural variations on chromosome 19 suggest a protective regulatory region in Alzheimer disease
Complex Traits and Polygenic Disorders
Collaborators: University of Miami, University Hospitals Cleveland Medical Center
Alzheimer’s diseaseBioinformaticsCopy number/structural variationPopulation genetics
Poster
Fri Oct 23
2:30 pm
Alzheimer Disease GRS association with Age-related Macular Degeneration is due to known association of PLEKHA1/ARMS2/HTRA1
Complex Traits and Polygenic Disorders
Collaborators: University of Miami, University of California, Los Angeles +2 more
Alzheimer’s diseaseGenetic epidemiologyNeurodegenerationPolygenic risk score
Bush Lab
Works in population genetics and computational genetics.
Poster
Wed Oct 21
2:30 pm
Ancestry-Linked Patterns of Haplotype-Specific Expression in a Multi-Ancestry Admixed Cohort
Evolutionary and Population Genetics
Collaborators: Institute of Computational Biology, University of Miami
HaplotypeGene regulationPopulation geneticsRNA
Poster
Fri Oct 23
2:30 pm
APOL1 haplotype analysis and channel flux assays suggest the M1 protective signal reflects the KIK haplotype, not p.N264K alone
Statistical Genetics and Genetic Epidemiology
Collaborators: Cleveland Clinic
Complex traitsGenetic epidemiologyHaplotypeLinkage disequilibrium
Schaffer Lab
Works in clinical genetics.
Poster
Wed Oct 21
2:30 pm
Scalable Multi-Gene MAVE Enables Functional Profiling and Therapeutic Rescue Screening of Loss of Trafficking ASD Variants
Molecular Effects of Genetic Variation
Collaborators: Oregon Health & Science University
Variant interpretationAutismCharacterization of syndromesNeurogenetics
Zhu Lab
Works in population genetics and computational genetics.
Plenary
Fri Oct 23
5:27 pm
Fine-mapping gene-gene and gene-environment interactions at phenotype-associated loci
Awards Recognition & Plenary Abstract Session III
BioinformaticsStatistical geneticsGene environment interactionComplex traits
Miranda Lab
Research group.
Moderator
Thu Oct 22
11:00 am
7 more presenters — research group not yet identified

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