Boston University at ASHG 2026

Oct 20–24, 2026 Montréal, Canada ~7.5k attendees Website

Boston University brings 6 presentations from 3 research groups to ASHG 2026 in Montréal. Its program centres on rare disease, population genetics and computational and clinical genetics. Siggers Lab presents links between autoimmune variants and T-cell enhancer activity, Zhang Lab examines Alzheimer’s transposable element insertions across ancestries, and Sebastiani Lab explores diet-related tryptophan transporters and cognitive and physical traits.

Organization	ASHG 2026 Attendance
Boston University Boston, Massachusetts	3 PhD Students
Siggers Labblogs.bu.edu/tsiggers/photos Wet + dry lab~9 people Studies immune-cell gene regulation using protein-binding microarrays and massively parallel reporter assays with genomics datasets. Focuses on transcription-factor specificity, cofactor recruitment at enhancers and immune signaling. 13 papers since 2024 › Targeting SUMOylation promotes cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma Nature Communications, 2025 Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming PLoS Biology, 2024 Rapid profiling of transcription factor–cofactor interaction networks reveals principles of epigenetic regulation Nucleic Acids Research, 2024 Source: OpenAlex author A5073024394 7 platforms and techniques › Runs Protein-binding microarrays (PBMs), Massively parallel reporter assays (MPRAs) Techniques Functional reporter studies, Cofactor recruitment at enhancers, Cooperatively binding transcription factors, Human monocytes, Monocyte/macrophage lineage factors Source: lab pages No funding stated · No openings posted	Poster Thu Oct 22 4:15 pm Part of Epigenomics Poster Thursday Session Allele-Specific Transcription Factor-Cofactor Assembly Links Autoimmune Noncoding Variants to T Cell Enhancer Activity Exhibit & Poster Hall · Board 7072T Complex traitsEpigeneticsExpression quantitative trait lociGenetic variation
Zhang Labsites.bu.edu/zhanglab Dry lab~19 people Analyzes whole-genome sequencing, RNA-seq, EHR, proteomics and MRI data with statistical genetics and machine learning. Studies Alzheimer’s disease mechanisms, risk and precision medicine. 38 papers since 2024 › Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy Cytokine & Growth Factor Reviews, 2025 Engineered‐Doping Strategy for Self‐Sufficient Reactive Oxygen Species Blossom to Amplify Ferroptosis/Cuproptosis Sensibilization in Hepatocellular Carcinoma Treatment Advanced Functional Materials, 2024 Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies Medicinal Research Reviews, 2024 Source: OpenAlex author A5100385966 Funded by NIA, NIA +2 more › NIA · 9/15/2025-6/30/2030 “new 5-year NIA grant (9/15/2025-6/30/2030) for a project titled “tRNA modifications regulating mitochondrial function and the mitochondrial proteome in AD/ADRD”” NIA · 9/15/2025-5/31/2030 “new 5-year NIA project (9/15/2025-5/31/2030) titled “tRNA Epitranscriptome and Translational Dysfunction in Alzheimer’s disease and related disorders (AD/ADRD)”” NIA · 8/05/2025-7/31/2030 “new 5-year NIA grant (8/05/2025-7/31/2030) titled “FunGen-xQTL: Unraveling the genetic basis of molecular functions in Alzheimer’s Disease”” +1 more on the lab page Source: lab pages 17 platforms and techniques › Analyzes Whole-genome sequencing, rRNA-depleted RNA-seq, Single-nuclei RNA sequencing, Spatial transcriptomics, Plasma and CSF proteomics, FreeSurfer brain MRI, Electronic health records, Genotype data Techniques Statistical modeling, Systems biology, Machine learning, xQTL analysis, Regulatory network analysis, Computational pipelines, GWAS, Cell-type deconvolution, Mouse models of AD/ADRD Source: lab pages Currently hiring › “We are always looking for talented and self-motivated graduate students and post-doc fellows” Source: lab positions page	Talk Fri Oct 23 2:15 pm Part of New Insights into the Genetic Basis of Neurodegenerative Conditions Large scale analysis of transposable element insertions in Alzheimer's disease across different ancestries Room 511/Level 5 Collaborators: University of Miami, Case Western Reserve University +1 more Alzheimer’s diseaseBioinformaticsCopy number/structural variationPopulation genetics
Sebastiani Lab Works in clinical genetics.	Poster Thu Oct 22 4:15 pm Part of Molecular Effects of Genetic Variation Poster Thursday Session Tryptophan Transporters Modulated by Diet Predict Cognitive and Physical Phenotypes: Implications for Precision Nutrition Exhibit & Poster Hall · Board 6086T Collaborators: Tufts Medical Center, Tufts University +1 more Gene environment interactionMulti-omicsMetabolomicsComplex traits
3 more presenters — research group not yet identified

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