Education Program 30
How donor stem cell transplants became safer and more widely available, through better graft-versus-host disease prevention, new treatments, and more donor options.
Using molecular testing and circulating tumor DNA to gauge follicular lymphoma risk, and choosing among bispecific antibodies, CAR-T cells and other newer drugs.
Why myeloproliferative neoplasms persist and progress despite therapy, from clone growth and inflammation to drug resistance, and new mutation-targeted treatments.
Care for people with vascular malformations, from their lived experience to gene-guided treatment with repurposed cancer drugs that block growth signaling.
Tailoring classic Hodgkin lymphoma treatment to risk, response and circulating tumor DNA to cure with less toxicity, plus personalized follow-up care.
Assessing and treating myelodysplastic syndromes, marrow failure cancers of older adults that can turn into acute myeloid leukemia, using newer risk systems.
How military service and toxic exposures shape blood cancers in US veterans, including B-cell cancers and clonal hematopoiesis, and remote clinical trials for them.
How education, training exchanges, mentorship and research networks can grow the hematology workforce and improve blood disease care in low-resource regions.
Chronic lymphocytic leukemia in the targeted-drug era, covering clonal evolution, choosing and sequencing therapies, and transformation into aggressive lymphoma.
Why demand for doctors treating non-cancer blood disorders outpaces supply, and how virtual care and AI language models can widen access.
The fast-changing treatment of diffuse large B-cell lymphoma, from new first-line combinations to CAR-T cells, bispecific antibodies and other targeted drugs.
How to evaluate unexplained cyanosis, recognize inherited or acquired methemoglobinemia with lab tests, and manage it without costly unnecessary workups.
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Laboratory Testing in MethemoglobinemiaLab diagnosis of methemoglobinemia and sulfhemoglobinemia, where altered hemoglobin carries oxygen poorly, and test pitfalls in inherited versus acquired cases.
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Later side effects of CAR-T therapy, including low blood counts, infections and immune problems, and how to monitor, prevent and treat them.
How clonal hematopoiesis, the age-related spread of mutated blood cells, fuels inflammation and artery and vein clots, and whether anti-inflammatory drugs help.
Genetic diagnosis of inherited red cell membrane and enzyme disorders, and treatment with pyruvate kinase activators, stem cell transplant or gene therapy.
Sickle cell disease pain, from new insights into its biology to managing it at the level of health systems, strategies, and individual treatments.
How gene-fusion biology in childhood acute myeloid leukemia is shaping targeted and antibody-drug conjugate treatments beyond standard chemotherapy.
Challenges as people with thalassemia live longer, including pregnancy, cheaper and safer gene therapy, and aging with the non-transfusion-dependent form.
How iron deficiency, often from heavy periods, harms women before and during pregnancy and affects fetal brain development, with diagnosis and treatment strategies.
Multiple myeloma care today, covering T-cell redirecting therapy at early relapse, options after CAR-T failure, and maintenance for high-risk patients.
Evidence-based treatment of primary and secondary central nervous system lymphoma, including care of older patients and new immunotherapies and targeted drugs.
How to diagnose inherited and acquired neutropenia and treat it with growth factor drugs, stem cell transplant, new targeted therapies and supportive care.
Caring for patients who cannot receive blood transfusions, by choice or for lack of compatible blood, in surgery and blood cancer treatment.
Hard decisions in chronic myeloid leukemia after 25 years of kinase inhibitors, including drug choice, stopping treatment, progression, and pregnancy planning.
Transfusion for sickle cell disease patients with antibodies against donor blood, from pre-transplant planning to finding matched units and treating reactions.
Menin inhibitors and other targeted drugs for acute myeloid leukemia, their use with frontline therapy, resistance to them and next-generation agents.
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Future of Targeted Therapies in AMLWhere acute myeloid leukemia treatment is heading, from new chemotherapy backbones and targeted drug pairings to next-generation drugs that overcome resistance.
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Risk grading of pulmonary embolism, clot-dissolving and catheter treatments for large vein clots, and preventing long-term leg damage after deep vein thrombosis.
How blinatumomab, CAR-T cells and other immunotherapies are reshaping acute lymphoblastic leukemia care and reducing chemotherapy across all ages.
Heart disease, stroke, and cognitive decline in adults aging with sickle cell disease, and how heart ultrasound and other tools guide prevention and care.
Diagnosing and managing inherited platelet and fibrinogen disorders and rare clotting factor deficiencies, where care relies on expert consensus more than trials.
Scientific Program 16
Old and new tools, from biochemistry and mouse models to spatial gene mapping and AI, revealing weak points and treatment biomarkers in multiple myeloma.
Immune signals shape blood stem cells from before birth onward, and immune cells police and remove damaged or pre-cancerous stem cells throughout life.
Protein shape, force-sensitive interactions, and clot architecture govern how blood clots form and dissolve, pointing to new ways to treat bleeding.
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Structural Insights into MechanismsHow an enzyme chemically modifies vitamin K dependent proteins, and how that step shapes blood clotting control, bone building, and blood vessel signaling.
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Novel Regulators of HemostasisHow the redox state of disulfide bonds in clotting proteins shapes their structure and autoantibody targeting in hemophilia A and antiphospholipid syndrome.
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Novel Regulators of FibrinolysisHow fibrin network structure, fiber packing, and mechanical tension decide how easily clots dissolve, and using clot mechanics as disease biomarkers.
Blood-clotting disorders driven by antibodies to platelet factor 4, including heparin- and vaccine-induced forms, compared on causes, diagnosis, and treatment.
Lab-built vessels on chips and large-vessel models reproduce how clots form under real flow, plus imaging that finds clots and delivers drugs to them.
Detecting the few leukemia cells left after treatment in acute myeloid leukemia, which tests to use when, and how to kill the survivors.
Iron balance from fetal life to old age, what goes wrong in deficiency and overload, and the pathways being targeted to treat iron-related disorders.
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The Role of Iron in Disease ProgressionIron overload in myelodysplastic syndromes, built up by failed red cell production and repeated transfusions, and how it pushes disease toward acute leukemia.
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AI, spatial multi-omics, epigenetics, and genetics are reshaping how blood cancers are diagnosed and classified in the pathology lab.
Every stage of the RNA life cycle, from splicing to chemical marks, shapes blood stem cells and blood cancers, pointing to new treatments.
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Novel Uses of RNA as TherapeuticsSynthetic RNAs that exploit faulty splicing to kill cancer cells with splicing-factor mutations, and mRNA vaccines against mis-spliced protein fragments.
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New Frontiers in RNA BiologySmall RNAs that carry sugar chains and sit on the cell surface, how chemistry finds them, and what they mean for immunity.
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Cell therapies built for blood cancers now treat autoimmune disease by wiping out B cells, raising questions of patient selection, biomarkers, and toxicity.
Safer clot prevention by selectively blocking the platelet signals that grow a clot, instead of shutting platelets down and raising bleeding risk.
Memory T cells that stay put in tissues drive chronic inflammation after infection, in tumors, and after transplant, and the pathways keeping them alive.
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Trm Phenotype and FunctionsHow T cells come to reside permanently in tissues during infection and cancer, how to study them, and therapies that harness them.
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Coming to Trms with GVHDTissue-resident memory T cells that sustain chronic graft-versus-host disease, the stem-like and progenitor subsets in target organs, and how they mature.
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Mutant blood cell clones in bone marrow failure, and how sequencing reveals whether they drive recovery, reversion, or progression to a myeloid cancer.
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Clonal Dominance in VEXASAn adult-onset inflammatory blood disorder caused by mutation of one protein-tagging enzyme, and how extra mutations shape inflammation and treatment.
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Escape Clones in Immune Mediated BMFHow blood stem cells in aplastic anemia dodge attacking T cells by disabling a tissue-type gene, repeatedly and independently, years before diagnosis.
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Blood stem cells do not share one uniform niche, and location, chromosome dosage, and body-wide feedback shape them in development, disease, and aging.
Metabolism drives red blood cell production, and targeting sugar, nucleotide, amino acid, and mitochondrial pathways could fix faulty production in thalassemia.
Genomic tools and better disease models are changing how inherited blood disorders in children are found, understood, and managed.
Scientific Symposia 6
Using AI trained on patient data to predict which T cell states make CAR-T therapy work, moving cell design beyond trial and error.
How to design clinical trials that alter the gut microbiome in blood cancers, including fecal microbiota transplants to prevent graft-versus-host disease.
Editing blood stem cells and making CAR-T cells inside the body, using viral and non-viral delivery to avoid costly manufacturing and harsh conditioning.
Growing red blood cells in the lab for transfusion, and the hurdles left in progenitor supply, differentiation, high-density culture, and first human studies.
Single-cell and spatial maps of bone marrow in acute myeloid leukemia and myelodysplastic neoplasms, showing how immune cell niches help tumors evade immunity.
New tools including multiomics, protein design, functional genomics, and AI applied to how blood clots form and dissolve, and to bleeding disorders.
Special Interest Sessions 18
Networking breakfast for hematology innovators and investors, introducing a new society platform for turning blood research into companies and products.
Ten years of the hematology journal Blood Advances, revisiting its most influential clinical trials, basic science studies and practice guidelines.
How genetic ancestry shapes blood disease biology, genomic interpretation, and drug discovery, and how to build it into study design.
Easing hematology clinic workload through primary care partnerships, teamwork with advanced practice providers, and AI tools that streamline workflows.
New evidence-based guidance on oral versus intravenous iron for iron deficiency, with or without anemia, in children, pregnancy, and chronic blood loss.
Guideline advice for light-chain amyloidosis on first-line therapy, stem cell transplant, response-adapted treatment, and relapsed disease.
Surviving early academic careers in hematology, from non-academic career paths and diversified funding to imposter syndrome, saying no, and negotiating.
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How FDA priorities, investor reactions to regulatory uncertainty, and new modeling tools shape the development of hematology discoveries into therapies.
Case studies showing how real-world multiple myeloma data reveal treatment patterns, outcomes in underrepresented groups, and care gaps, along with their limits.
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Practical strategies for medical educators on time management, wellness, inclusive learning spaces, and teaching with AI, apps, and social media.
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Quality improvement methods for hematology practice, from spotting care gaps and writing aim statements to choosing measures that show real change.
Using sickle cell disease registries and health records to build external control arms, track safety after approval, and define pain as a trial endpoint.
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Generative AI in hematology, from chatbot tools usable today to autonomous agents, and safeguards for reliability, bias, and human oversight.
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Limitations and Risks of Generative AIWhere generative AI fails in medicine, from hallucinations and bias to rare-disease blind spots, and how validation, governance, and human oversight reduce harm.
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Multi-Agent AI systemsAI agents that reason, plan, use tools, and work together on complex scientific and clinical tasks, and how they may change the hematologist's role.
Better sickle cell disease trial endpoints than pain-crisis counts, such as biomarkers, combined measures, and patient-reported outcomes reflecting daily burden.
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Supporting trainees' careers and research funding in a tough political climate, AI guidelines for fellows, and how applicants signal interest in programs.
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How hematologists and fellows can influence healthcare reform on research funding, Medicaid, and hospital budgets, and how policy shapes health inequities.
Negotiation strategies for women in hematology, covering how to negotiate for roles and future opportunities and build lasting advocacy networks.