ASHG 2026 · Tier 2–3 Academic

Wellcome Sanger Institute at ASHG 2026

Name: ASHG 2026 Annual Meeting
Start: 2026-10-20
End: 2026-10-24
Location: Montréal

Cambridge, UK

Wellcome Sanger Institute at ASHG 2026 in Montréal: 8 presentations (5 posters, 2 lightning talks, 1 platform talk); 4 research groups.

presentations on the program

research groups identified

sessions invited to or moderated

Reviewers’ Choice abstracts

Explore everyone at ASHG 2026 →

Organization	ASHG 2026 Attendance
Wellcome Sanger Institute Cambridge, UK	3 PhD Students · 2 Postdocs · 1 Staff Scientist
Anderson Groupsanger.ac.uk/group/anderson-group Wet + dry lab~10 people Uses whole-exome, whole-genome and single-cell RNA sequencing plus genome-wide CRISPR screens to study immune-mediated disease. Focuses on inflammatory bowel disease, drug targets and treatment response. 31 papers since 2024 › Performance of deep-learning-based approaches to improve polygenic scores Nature Communications, 2025 Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine BMJ Open, 2024 shaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores The American Journal of Human Genetics, 2024 Source: OpenAlex author A5020962383 Funded by Crohn's and Colitis Foundation › Crohn's and Colitis Foundation, Genetics Initiative · active “they part-fund our single-cell gut eQTL work.” Source: lab pages 11 platforms and techniques › Works with single-cell RNA sequencing, whole-exome sequencing, whole-genome sequencing, DNA sequencing, SNP microarray intensity data Techniques high-throughput screens, genome-wide CRISPR screens, primary immune cells, iPSC-derived immune cells, GWAS, functional follow-up Source: lab pages Currently hiring › “We’re always on the lookout for motivated people to join the group” Source: lab positions page	Poster Wed Oct 21 2:30 pm Deep generative modelling of large-scale blood single-cell RNA sequencing defines cell type-specific, clinically relevant archetypes in inflammatory bowel disease Artificial Intelligence and Machine Learning Collaborators: Clinical Research Institute, Institute of Rheumatology Complex diseasesGenomicsMachine learningPrecision medicine Poster Thu Oct 22 4:15 pm Isoform usage landscape in the gut revealed by long-read single-cell RNA-seq Molecular Effects of Genetic Variation Collaborators: Open Targets, Centre for Inflammation Research Alternative splicingAutoimmune disorderGastrointestinal systemGene regulation Moderator Fri Oct 23 11:00 am Single-Cell, Multi-Omics, and Liquid Biopsy Approaches to Decode Lung Disease Genetics and Biomarkers
Trynka Groupsanger.ac.uk/group/trynka-group Wet + dry lab~11 people Generates single-cell transcriptomic, CRISPR-screen and high-throughput imaging data in immune cells. Links genetic variants to immune disease mechanisms and therapeutic discovery. 32 papers since 2024 › A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes Nature Biotechnology, 2025 Human Genetics and Genomics for Drug Target Identification and Prioritization: Open Targets’ Perspective Annual Review of Biomedical Data Science, 2024 AI and immunology Immunity, 2024 Source: OpenAlex author A5091121983 Funded by Chan Zuckerberg Initiative (CZI) › Chan Zuckerberg Initiative (CZI), Ancestry Networks for the Human Cell Atlas · active Philanthropic science funding from the Chan Zuckerberg Initiative. “The Ancestry Networks for the Human Cell Atlas grant is awarded by the Chan Zuckerberg Initiative (CZI).” Source: lab pages 9 platforms and techniques › Runs Single-cell transcriptomics, Pooled CRISPR screens, Arrayed CRISPR screens, High-throughput imaging platform Techniques Single-cell eQTL mapping, CRISPR perturbation, High-content imaging, Immune phenotyping, Primary immune cells Source: lab pages No openings posted	Talk Thu Oct 22 9:00 am From eQTL to function: Dissecting genetic control of Treg suppression New Adventures in Molecular Trait Mapping Collaborators: Open Targets, Human Technopole Autoimmune disorderExpression quantitative trait lociGenome editing/CRISPRSingle-cell Poster Thu Oct 22 4:15 pm Mapping immune-mediated disease variants to cellular function through multimodal profiling of CD4+ T cell activation Omics Technologies Collaborators: Human Technopole, Open Targets Complex diseasesGenotype-phenotype correlationsImmune systemMulti-omics
Hurles Groupsanger.ac.uk/group/hurles-group Wet + dry lab~6 people Studies rare developmental conditions using experimental cell models, exon-arrayCGH and trio exome sequencing. Works with DDD, Genomics England and PAGE. 36 papers since 2024 › Prospective study design and data analysis in UK Biobank Science Translational Medicine, 2024 De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome Nature, 2024 Examining the role of common variants in rare neurodevelopmental conditions Nature, 2024 Source: OpenAlex author A5068997042 Funded by Health Innovation Challenge Fund, Wellcome Trust › Health Innovation Challenge Fund · active “DDD is funded by the Health Innovation Challenge Fund” Wellcome Trust · active “Biomedical charity that funds most of our science” Source: lab pages 7 platforms and techniques › Runs high resolution exon-arrayCGH, trio exome sequencing Techniques experimental cell models, clinical variant filtering, CNV calling, large-scale mosaicism detection, UPD detection Source: lab pages No openings posted	Talk Wed Oct 21 1:35 pm Analysis of 184,786 developmental disorder trios identifies over a hundred novel DD-associated genes and candidate haplolethal genes Clinical Genetics Across the Lifespan: From Gene Discovery to Prenatal, Developmental, and Pharmacogenomic Insights Collaborators: Radboud University Medical Center Identification of disease genesIntellectual and developmental disabilityExome/genome sequencingMendelian disorder Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Analysis of 184,786 developmental disorder trios identifies over a hundred novel DD-associated genes and candidate haplolethal genes Mendelian Phenotypes Collaborators: Radboud University Medical Center Exome/genome sequencingIdentification of disease genesIntellectual and developmental disabilityMendelian disorder
Vento-Tormo Groupsanger.ac.uk/group/vento-tormo-group Wet + dry lab~27 people Studies tissue organisation using spatial multiomics, whole-genome sequencing, AI/ML and single-cell techniques. Builds disease models for women’s health and human development. 4 papers since 2024 › An integrated single cell and spatial omics atlas of human prenatal development bioRxiv (Cold Spring Harbor Laboratory), 2026 Abstract 158: PI3Kδ in CD4+ T cells protects against lung metastases through IFNγ-induced tumor senescence. Cancer Research, 2026 Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithelial tissues bioRxiv (Cold Spring Harbor Laboratory), 2026 Source: OpenAlex author A5096312176 Funded by Wellcome, CZI +6 more › Wellcome · active “Wellcome” CZI · active “CZI” Wellcome Leap · active “wellcome-leap-logo” +5 more on the lab page Source: lab pages 10 platforms and techniques › Works with spatial multiomics, whole-genome sequencing, single-cell techniques Techniques spatial genomics, artificial intelligence and machine learning, gene editing, single-cell multiomics, in vitro models, large-scale perturbations, routine histopathology Source: lab pages Currently hiring › “We are actively looking for motivated students and postdocs to join the lab.” Source: lab positions page	Talk Wed Oct 21 2:07 pm Integrating GWAS with a multimodal atlas of the female reproductive system reveals critical cell types and pathways in gynaecological disorders Clinical Genetics Across the Lifespan: From Gene Discovery to Prenatal, Developmental, and Pharmacogenomic Insights Collaborators: University of Cambridge GenomicsMulti-omicsReproductive geneticsWomen's health Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Integrating GWAS with a multimodal atlas of the female reproductive system reveals critical cell types and pathways in gynaecological disorders Prenatal, Perinatal, Reproductive, and Developmental Genetics Collaborators: University of Cambridge Complex diseasesGenomicsMulti-omicsReproductive genetics

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