ASHG 2026 · Tier 1 Academic

University of Southern California at ASHG 2026

Los Angeles, California

University of Southern California at ASHG 2026 in Montréal: 16 presentations (12 posters, 3 platform talks, 1 featured symposium); 10 research groups.

16
presentations on the program
10
research groups identified
1
sessions invited to or moderated
2
Reviewers’ Choice abstracts

Explore everyone at ASHG 2026 →

OrganizationASHG 2026 Attendance
University of Southern California
Los Angeles, California
8 PhD Students · 3 Postdocs · 2 PIs · 1 Faculty
MancusoLabgithub.com/mancusolab/ma-focus
Dry lab~5 people
Develops computational methods integrating GWAS with gene expression, protein abundance, chromatin markers and sequencing data. Studies complex-disease mechanisms and genetic architecture across diverse human populations.
53 papers since 2024
Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk
Nature Genetics, 2025
A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
Cell Genomics, 2024
Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions
The American Journal of Human Genetics, 2024
Source: OpenAlex author A5029082038
7 platforms and techniques
Techniques
GWAS integration with molecular phenotypes, Transcriptome-wide association study fine-mapping, Multi-ancestry molecular QTL fine-mapping, Single-cell molecular QTL mapping, Variational factor analysis, Admixture mapping, PCA variable selection
Source: lab pages
Currently hiring
“We are actively recruiting highly motivated graduate students and postdocs with a capable computational/quantitative background.”
Source: lab positions page
No funding stated
Poster
Thu Oct 22
4:15 pm
Multi-ancestry Fine Mapping Using Continuous Genetic Similarity
Statistical Genetics and Genetic Epidemiology
Computational toolsIdentification of disease genesPopulation geneticsStatistical genetics
Poster
Thu Oct 22
4:15 pm
★ Reviewers’ Choice
scFM: An efficient statistical fine-mapping approach for eQTLs using large-scale single-cell data
Statistical Genetics and Genetic Epidemiology
Computational toolsStatistical genetics
Talk
Sat Oct 24
9:00 am
An end-to-end differentiable, inferential model of stabilizing selection for molecular quantitative traits
The Selection Paradox: Why Disease Variants Persist
Collaborators: Dana-Farber Cancer Institute
Expression quantitative trait lociNatural selectionPopulation geneticsQuantitative trait
Chiang.Labchianglab.usc.edu
Dry lab~12 people
Generates whole-genome sequencing data and analyzes GWAS and biobank data with ARG methods and polygenic scores. Studies complex traits in Native Hawaiians and diverse populations.
28 papers since 2024
The Promise of Inferring the Past Using the Ancestral Recombination Graph
Genome Biology and Evolution, 2024
A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
Cell Genomics, 2024
Imputation accuracy across global human populations
The American Journal of Human Genetics, 2024
Source: OpenAlex author A5053877118
Funded by NHGRI, USC-UH Multiethnic Cohort +1 more
NHGRI, F31 predoctoral fellowship · active
“Supported by a F31 predoctoral fellowship from NHGRI”
USC-UH Multiethnic Cohort, T32 Postdoctoral Training Program · active
“through the USC-UH Multiethnic Cohort T32 Postdoctoral Training Program”
NIH · active
“through NIH grants in the lab”
Source: lab pages
10 platforms and techniques
Works with
Whole-genome sequencing, GWAS, Array-genotyped SNPs, TOPMed imputation reference panel
Techniques
Ancestral recombination graphs, Polygenic risk scores, Machine-learning dietary scores, Local ancestry analysis, Demographic inference, Recombination maps
Source: lab pages
Currently hiring
“We currently have space and funding for one or more postdoctoral fellows in genetic epidemiology and population genetics to join our group.”
Source: lab positions page
Poster
Thu Oct 22
4:15 pm
★ Reviewers’ Choice
The trans-Pacific voyage that shaped the pattern of genetic variation and enrichment of functional alleles in Native Hawaiians
Evolutionary and Population Genetics
Collaborators: Stanford University
Evolutionary geneticsGenomicsPopulation geneticsPopulation structure
Poster
Thu Oct 22
4:15 pm
Preliminary cis-eQTL mapping in an ongoing multi-ethnic prostate cancer pilot study
Cancer
Collaborators: University of Colorado Anschutz, Baylor College of Medicine
CancerExpression quantitative trait lociRNA-seqGenetic epidemiology
Durvasula Labsites.usc.edu/durvasula
Dry lab~6 people
Develops statistical tools for genomic and UK Biobank data. Studies gene-environment interactions, human evolution and natural selection in disease and traits.
18 papers since 2024
Distinct explanations underlie gene-environment interactions in the UK Biobank
The American Journal of Human Genetics, 2025
Deciphering the impact of genomic variation on function
Nature, 2024
Accurate inference of population history in the presence of background selection
bioRxiv (Cold Spring Harbor Laboratory), 2024
Source: OpenAlex author A5051535161
5 platforms and techniques
Techniques
polygenic scores, genome sequencing, deep learning models, population genomics, methylation-gene expression modeling
Source: lab pages
No funding stated · No openings posted
Symposium
Fri Oct 23
8:20 am
Gene-environment interactions shape complex disease and trait architecture
Emergence of Complex Traits at the Intersection of Genomics, Exposomic, and Time
Evolutionary Biology of Physical Activity Labraichlenlab.com
Wet lab~4 people
Links human evolution, physical activity and health using laboratory biomechanics, epidemiology, neuroscience and field studies. Applies evolutionary models to improve health today.
62 papers since 2024
Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake
Nature Food, 2025
Energy expenditure and obesity across the economic spectrum
Proceedings of the National Academy of Sciences, 2025
Sedentary behavior and lifespan brain health
Trends in Cognitive Sciences, 2024
Source: OpenAlex author A5038352154
Funded by National Science Foundation, National Institutes of Health
National Science Foundation, Doctoral Dissertation Improvement Grant · February 2021
“Katie Sayre receives funding from the National Science Foundation for her Doctoral Dissertation Improvement Grant”
National Institutes of Health, R56 grant · October 2020
“Dr. [name] is a Principal Investigator on a National Institutes of Health R56 grant”
Source: lab pages
9 platforms and techniques
Runs
Accelerometers, Heart-rate monitors, GPS
Techniques
Evolutionary genomics, Comparative biomechanics and physiology, Exercise and cognitive challenge interventions, Field studies, Human hunter-gatherers, Health and chronic-disease biomarkers
Source: lab pages
Currently hiring
“The Evolutionary Biology of Physical Activity Lab is accepting graduate students.”
Source: lab positions page
Poster
Fri Oct 23
2:30 pm
Ancient Selection on the BDNF Val66Met Variant Reveals Evolutionary Insights into Human Neurological Disease Susceptibility
Evolutionary and Population Genetics
NeurogeneticsNatural selectionAncient DNAPopulation genetics
Gazal Labgazal-lab.org/lab-members
Dry lab~9 people
Develops statistical methods using UK Biobank, 23andMe and functional datasets. Studies human-disease genetic architecture, selection and inflammatory disease.
24 papers since 2024
Deciphering the impact of genomic variation on function
Nature, 2024
Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation
bioRxiv (Cold Spring Harbor Laboratory), 2024
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Science, 2024
Source: OpenAlex author A5042815092
Funded by NHGRI, NIGMS
NHGRI, Pathway to Independence Award · active
“His work is supported by an NHGRI Pathway to Independence Award and an NIGMS Maximizing Investigators Research Award (MIRA) for Early Stage Investigators.”
NIGMS, Maximizing Investigators Research Award (MIRA) for Early Stage Investigators · active
“His work is supported by an NHGRI Pathway to Independence Award and an NIGMS Maximizing Investigators Research Award (MIRA) for Early Stage Investigators.”
Source: lab pages
8 platforms and techniques
Techniques
population genetics, genetic epidemiology, functional genomics, S-LDSC, SNP-to-gene linking, fine-mapping, polygenic risk scores, CT-FM and CT-FM-SNP
Source: lab pages
Currently hiring
“We are recruiting highly motivated graduate students and postdocs with computational background.”
Source: lab positions page
Poster
Fri Oct 23
2:30 pm
Time-stratified evolutionary constraint reveals distinct layers of genome function and disease architecture
Evolutionary and Population Genetics
Collaborators: Uppsala University, Broad Institute +1 more
Evolutionary geneticsEvolutionNatural selectionGene regulation
Mangul Labmangul-lab-usc.github.io
Dry lab~24 people
Analyzes RNA-seq, DNA-seq, TCR-Seq and metagenomic data with computational, statistical and machine-learning methods. Uses include sepsis, immunogenomics and emerging viral-variant detection.
41 papers since 2024
Analysis of metagenomic data
Nature Reviews Methods Primers, 2025
The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches
Frontiers in Immunology, 2024
Climate warming, environmental degradation and pollution as drivers of antibiotic resistance
Environmental Pollution, 2024
Source: OpenAlex author A5017101305
Funded by National Science Foundation, National Institutes of Health +1 more
National Science Foundation · active
“Mangul Laboratory is supported by the National Science Foundation (NSF) grants 2041984 and 2316223”
National Institutes of Health, R01AI173172 · active
The NIH's standard multi-year research project grant.
“the National Institutes of Health (NIH) grant R01AI173172.”
National Science Foundation, NSF EAGER Award
“NSF EAGER Award, “EAGER: Developing a framework to identify and mitigate perceptual and technical barriers in code sharing”
Source: lab pages
11 platforms and techniques
Analyzes
RNA-seq, DNA-seq, TCR-Seq, Ion Torrent RNA-Seq, PacBio
Techniques
Computational, statistical and machine-learning models, Metagenomic classification, T-cell receptor repertoire profiling, Wastewater genomic surveillance, DNA methylation analysis, Sepsis mortality prediction
Source: lab pages
Currently hiring
“We are actively recruiting highly motivated graduate students and postdocs with a capable computational background.”
Source: lab positions page
Talk
Sat Oct 24
8:15 am
Why do high-effect common variants persist in human populations?
The Selection Paradox: Why Disease Variants Persist
Evolutionary geneticsComplex traitsNatural selectionPopulation genetics
Shu Lab at USCaprilshulab.com
Dry lab~8 people
Uses machine learning and statistical approaches on genetic, clinical, neuroimaging, single-cell RNA-seq and spatial transcriptomics data. Applies these to autism and neurodevelopmental disorders.
30 papers since 2024
Unlocking High‐Speed and Energy‐Efficiency: Integrated Convolution Processing on Thin‐Film Lithium Niobate
Laser & Photonics Review, 2025
Climate factors associated with cancer incidence: An ecological study covering 33 cancers from population-based registries in 37 countries
PLOS Climate, 2024
Human parasitic infections of the class Adenophorea: global epidemiology, pathogenesis, prevention and control
Infectious Diseases of Poverty, 2024
Source: OpenAlex author A5100723541
Funded by Southern California Environmental Health Sciences Center
Southern California Environmental Health Sciences Center, pilot grant · active
“Our lab received the pilot grant from Southern California Environmental Health Sciences Center.”
Source: lab pages
11 platforms and techniques
Analyzes
single-cell RNA-seq, spatial transcriptomics, methylation capture sequencing, Infinium MethylationEPIC array, ChIP-Seq
Techniques
machine learning, single-cell transcriptomics, DNA methylation, histone modification, single-cell multiomics, GWAS
Source: lab pages
No openings posted
Poster
Wed Oct 21
2:30 pm
Rare CNV burden and Heritability of Machine Learning-Derived Autism Subtypes
Complex Traits and Polygenic Disorders
Collaborators: Boston Children's Hospital, Saban Research Institute
AutismComplex traitsGenetic epidemiologyGenotype-phenotype correlations
Center for Genetic Epidemiologykeck.usc.edu/genetic-epidemiology-center
Dry lab~11 people
Develops statistical methods for GWAS, next-generation sequencing, DNA methylation, gene expression and proteomics data. Studies genetic risk and disease disparities across multiethnic populations.
230 papers since 2024
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
Nature, 2024
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction
Nature Genetics, 2024
Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Nature Genetics, 2024
Source: OpenAlex author A5063459619
Funded by National Institute of Environmental Health Sciences, U.S. Environmental Protection Agency +1 more
National Institute of Environmental Health Sciences, Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE) · active
“CIRCLE is a National Institute of Environmental Health Sciences/U.S. Environmental Protection Agency–funded program project”
U.S. Environmental Protection Agency, Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE) · active
“CIRCLE is a National Institute of Environmental Health Sciences/U.S. Environmental Protection Agency–funded program project”
National Heart, Lung, and Blood Institute, Trans-omics for Precision Medicine (TOPMed) · active
“The TOPMed program, which is supported by the National Heart, Lung, and Blood Institute”
Source: lab pages
13 platforms and techniques
Analyzes
Genome-wide association studies (GWAS), Next-generation sequencing, Whole-exome sequencing, Whole-genome sequencing, Genotyping arrays, DNA methylation, Proteomics measurements, Metabolomics
Techniques
Fine-mapping, Polygenic risk score analyses, Bayesian variable selection, Integrative genomic analyses, Demographic inference
Source: lab pages
Currently hiring
“Faculty recruitment in the center is underway”
Source: lab positions page
Campbell Lab
Works in population genetics and computational genetics.
Poster
Thu Oct 22
4:15 pm
CHIASMA Improves Fine-Scale Recombination Inference and Haplotype-Based Selection Discovery in Diverse Human Populations
Artificial Intelligence and Machine Learning
BioinformaticsMachine learningComputational toolsEvolutionary genetics
Poster
Thu Oct 22
4:15 pm
Ancient Selection and a Shared Ancestral Polymorphism Shape Type 2 Diabetes Risk in North African Populations
Evolutionary and Population Genetics
Collaborators: Institut Pasteur de Tunis, Umm al-Qura University
Evolutionary geneticsDiabetesGene environment interactionNatural selection
Division of Biostatistics and Health Data Science
Works in population genetics.
Talk
Thu Oct 22
8:30 am
Scalable fine-mapping of single-cell eQTL data using variational count-based models
New Adventures in Molecular Trait Mapping
Collaborators: University of Pennsylvania, Broad Institute
Single-cellGenetic mappingExpression quantitative trait lociLinkage disequilibrium
3 more presenters — research group not yet identified

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