Develops computational methods integrating GWAS with gene expression, protein abundance, chromatin markers and sequencing data. Studies complex-disease mechanisms and genetic architecture across diverse human populations.
Generates whole-genome sequencing data and analyzes GWAS and biobank data with ARG methods and polygenic scores. Studies complex traits in Native Hawaiians and diverse populations.
28 papers since 2024
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The Promise of Inferring the Past Using the Ancestral Recombination Graph
Genome Biology and Evolution, 2024
A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
Cell Genomics, 2024
Imputation accuracy across global human populations
Develops statistical tools for genomic and UK Biobank data. Studies gene-environment interactions, human evolution and natural selection in disease and traits.
18 papers since 2024
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Distinct explanations underlie gene-environment interactions in the UK Biobank
The American Journal of Human Genetics, 2025
Deciphering the impact of genomic variation on function
Nature, 2024
Accurate inference of population history in the presence of background selection
Emergence of Complex Traits at the Intersection of Genomics, Exposomic, and Time
Evolutionary Biology of Physical Activity Labraichlenlab.com
Wet lab~4 people
Links human evolution, physical activity and health using laboratory biomechanics, epidemiology, neuroscience and field studies. Applies evolutionary models to improve health today.
62 papers since 2024
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Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake
Nature Food, 2025
Energy expenditure and obesity across the economic spectrum
Proceedings of the National Academy of Sciences, 2025
Evolutionary genomics, Comparative biomechanics and physiology, Exercise and cognitive challenge interventions, Field studies, Human hunter-gatherers, Health and chronic-disease biomarkers
Develops statistical methods using UK Biobank, 23andMe and functional datasets. Studies human-disease genetic architecture, selection and inflammatory disease.
24 papers since 2024
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Deciphering the impact of genomic variation on function
Nature, 2024
Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation
bioRxiv (Cold Spring Harbor Laboratory), 2024
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
“His work is supported by an NHGRI Pathway to Independence Award and an NIGMS Maximizing Investigators Research Award (MIRA) for Early Stage Investigators.”
NIGMS, Maximizing Investigators Research Award (MIRA) for Early Stage Investigators · active
“His work is supported by an NHGRI Pathway to Independence Award and an NIGMS Maximizing Investigators Research Award (MIRA) for Early Stage Investigators.”
Analyzes RNA-seq, DNA-seq, TCR-Seq and metagenomic data with computational, statistical and machine-learning methods. Uses include sepsis, immunogenomics and emerging viral-variant detection.
41 papers since 2024
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Analysis of metagenomic data
Nature Reviews Methods Primers, 2025
The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches
Frontiers in Immunology, 2024
Climate warming, environmental degradation and pollution as drivers of antibiotic resistance
Uses machine learning and statistical approaches on genetic, clinical, neuroimaging, single-cell RNA-seq and spatial transcriptomics data. Applies these to autism and neurodevelopmental disorders.
30 papers since 2024
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Unlocking High‐Speed and Energy‐Efficiency: Integrated Convolution Processing on Thin‐Film Lithium Niobate
Laser & Photonics Review, 2025
Climate factors associated with cancer incidence: An ecological study covering 33 cancers from population-based registries in 37 countries
PLOS Climate, 2024
Human parasitic infections of the class Adenophorea: global epidemiology, pathogenesis, prevention and control
Develops statistical methods for GWAS, next-generation sequencing, DNA methylation, gene expression and proteomics data. Studies genetic risk and disease disparities across multiethnic populations.
230 papers since 2024
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Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
Nature, 2024
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction
Nature Genetics, 2024
Understanding the genetic complexity of puberty timing across the allele frequency spectrum