ASHG 2026 · Tier 1 Academic

University of Chicago at ASHG 2026

Name: ASHG 2026 Annual Meeting
Start: 2026-10-20
End: 2026-10-24
Location: Montréal

Chicago, Illinois

University of Chicago at ASHG 2026 in Montréal: 35 presentations (26 posters, 7 platform talks, 2 featured symposia); 16 research groups.

presentations on the program

research groups identified

sessions invited to or moderated

Reviewers’ Choice abstracts

Explore everyone at ASHG 2026 →

Organization	ASHG 2026 Attendance
University of Chicago Chicago, Illinois	18 PhD Students · 4 PIs · 4 Postdocs · 1 Faculty
Gilad Labgiladlab.uchicago.edu/labmembers Wet + dry lab~18 people Studies gene-regulatory evolution using bulk and single-cell RNA sequencing, ATAC-seq and comparative iPSC panels. Connects genetic variation to phenotypes in humans and primates. 10 papers since 2024 › Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids Genome Research, 2025 Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons Cell Genomics, 2024 Cell type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures Cell Genomics, 2024 Source: OpenAlex author A5014642082 Funded by NIH, NIH +1 more › NIH, F30 predoctoral fellowship · 5/30/2025 “Geena Woo was recently awarded a prestigious NIH predoctoral fellowship.” NIH, F31 Ruth L. Kirschstein National Research Service Award · 8/2023 “Erik was granted the NIH F31 Ruth L. Kirschstein National Research Service Award.” American Heart Association, Predoctoral Fellowship · 5/2023 “He was offered the American Heart Association Predoctoral Fellowship (declined).” Source: lab pages 9 platforms and techniques › Runs bulk RNA sequencing, single-cell RNA sequencing (scRNA-seq), ATAC-seq Techniques regulatory QTL mapping, mediation analysis, comparative iPSC models, directed stem cell differentiation, guided differentiation, cardiac organoids Source: lab pages Currently hiring › “The Gilad Lab continually seeks applications from prospective postdoctoral researchers.” Source: lab positions page	Poster Wed Oct 21 2:30 pm Evidence for regulatory gene expression variability in human cell types Molecular Effects of Genetic Variation Gene regulationRegulation of transcriptionGenomics Poster Wed Oct 21 2:30 pm A dispersion-based framework for evaluating clustering resolution in single-cell RNA-seq data Omics Technologies Single-cellRNA-seqBioinformaticsImmune system Poster Wed Oct 21 2:30 pm A single-cell resource for characterizing gene expression responses to drug toxicity across cell types and individuals Artificial Intelligence and Machine Learning Single-cellDeep learningPharmacogenomicsGene regulation Poster Wed Oct 21 2:30 pm ★ Reviewers’ Choice Functional characterization of divergent cis-regulatory elements in humans and chimpanzees at single-nucleotide resolution Molecular Effects of Genetic Variation Evolutionary geneticsGene regulationGenetic variationMulti-omics Talk Thu Oct 22 11:30 am Cis and trans contributions to cell type-specific regulatory evolution in primates Gene Regulatory Networks Across Development, Evolution, and Disease EpigeneticsSingle-cellMulti-omicsGene regulation Poster Thu Oct 22 4:15 pm ★ Reviewers’ Choice Comparative analysis of human and chimpanzee liver cell responses to innate immune stimulation Molecular Effects of Genetic Variation DifferentiationEvolutionGene regulationImmune system Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Characterizing regulatory mechanisms underlying divergence in gene expression fidelity between humans and chimpanzees Evolutionary and Population Genetics Gene regulationMulti-omicsQuantitative traitGenomics
LIU LAB @ UChicagoliulab.uchicago.edu Dry lab~8 people Combines statistical methods with RNA-seq, ChIP-seq, ATAC-seq, CUT&TAG, scRNAseq and scATACseq data. Studies trans gene regulation and disease biology. 17 papers since 2024 › Trans-eQTL mapping in gene sets identifies network effects of genetic variants Cell Genomics, 2024 Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines The American Journal of Human Genetics, 2024 Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts medRxiv, 2024 Source: OpenAlex author A5075969050 Funded by NIGMS › NIGMS, Maximizing Investigators’ Research Award (MIRA) (R35) · 2020 “Our lab received the NIGMS Maximizing Investigators’ Research Award (MIRA) (R35) to expand our research” Source: lab pages 10 platforms and techniques › Analyzes RNA-seq, ChIP-seq, ATAC-seq, CUT&TAG, scRNAseq, scATACseq Techniques CRISPR perturbations, trans-eQTL mapping, polygenic risk scores, GWAS Source: lab pages Currently hiring › “We are recruiting!” Source: lab positions page	Poster Wed Oct 21 2:30 pm The integration of trans-regulation and rare variant associations reveal novel pathology of Alzheimer’s disease Complex Traits and Polygenic Disorders Collaborators: Columbia University Alzheimer’s diseaseIdentification of disease genesStatistical geneticsRare variants Poster Wed Oct 21 2:30 pm ★ Reviewers’ Choice Linking Common and Rare Variant Associations Identifies Disease-Mediating Genes in Crohn’s Disease Complex Traits and Polygenic Disorders Collaborators: Broad Institute Complex diseasesAutoimmune disorderRare variantsGenetic variation Poster Thu Oct 22 4:15 pm The perturbome informs the genetic architecture of complex human traits and drug target identification Statistical Genetics and Genetic Epidemiology BioinformaticsGene regulationRare variantsStatistical genetics Talk Sat Oct 24 8:15 am OPERA: A Scalable Framework for Identifying Disease-Mediating Gene Programs from Perturb-seq Data Rethinking Genomic Discovery: New Methods for a Complex Genetic Landscape Statistical geneticsIdentification of disease genesGenome-wide association studyGenome editing/CRISPR
Pierce Labvoices.uchicago.edu/piercelab Dry lab~8 people Studies DNA methylation, sequencing and array measurements in GTEx tissues and arsenic-exposed Bangladeshi cohorts. Targets cancer susceptibility, arsenic toxicity, aging and prostate cancer disparities. 113 papers since 2024 › Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups Nature Genetics, 2025 DNA methylation correlates of chronological age in diverse human tissue types Epigenetics & Chromatin, 2024 The association of cigarette smoking with DNA methylation and gene expression in human tissue samples The American Journal of Human Genetics, 2024 Source: OpenAlex author A5065566745 6 platforms and techniques › Techniques DNA methylation QTL mapping, Mendelian randomization, Gene-environment interaction analysis, Sequencing-based fine-mapping, Telomere length measurement, DNA methylation clock algorithms Source: lab pages Currently hiring › “Our group has openings for doctoral students and postdoctoral scholars/fellows” Source: lab positions page No funding stated	Poster Thu Oct 22 4:15 pm Cigarette smoking shapes the adaptive immune transcriptome and B cell repertoire across human tissue types Cancer Collaborators: University of Pittsburgh Alternative splicingCancerImmune systemTranscriptome Poster Thu Oct 22 4:15 pm Extracting DNA methylation from long-read sequencing data at population scale: a validated framework applied to the All of Us cohort Omics Technologies Collaborators: University of Chicago Medicine Comprehensive Cancer Center EpigeneticsEpigenome-wide association studiesLong-read sequencingMethylation Poster Thu Oct 22 4:15 pm Multi-ancestry fine-mapping of the TERT/CLPTM1L locus and its pleiotropic effects on telomere length, blood cells, clonal hematopoiesis, and epigenetic aging. Molecular Effects of Genetic Variation Collaborators: University of Chicago Medicine Comprehensive Cancer Center, University of Washington +2 more CancerGenetic mappingGenetic variationGenome-wide association study
Ober Labober.bsd.uchicago.edu/people.php Wet + dry lab~14 people Studies asthma genetics using whole-genome/exome sequencing, SNP genotypes, DNA methylation, transcriptomic profiling and cell culture. Uses Hutterite, Amish and birth-cohort data to study disease risk. 58 papers since 2024 › Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity Archives of Pediatrics and Adolescent Medicine, 2024 Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop Journal of Allergy and Clinical Immunology, 2024 Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma Cell Genomics, 2024 Source: OpenAlex author A5016707790 Funded by NIAID › NIAID, Asthma and Allergy Center at UChicago · active “continue today as part of the NIAID-funded Asthma and Allergy Center at the UChicago” Source: lab pages 14 platforms and techniques › Analyzes whole-genome sequencing, whole-exome sequencing, genome-wide SNP genotypes, DNA methylation, transcriptomic profiling, mRNA and miRNA Techniques cell culture models, tissue culture, functional genomics, genome-wide association studies, genotype imputation, haplotype phasing, rhinovirus infection models, airway epithelial and smooth-muscle cell models Source: lab pages No openings posted	Poster Wed Oct 21 2:30 pm Context-specific eQTLs in upper airway immune cells during viral colds at the 17q12-21 childhood asthma locus Complex Traits and Polygenic Disorders Collaborators: Vanderbilt University Medical Center, National Institute of Allergy and Infectious Diseases +13 more AsthmaExpression quantitative trait lociGene environment interactionGene regulation Poster Fri Oct 23 2:30 pm Unmasking disease pathways: Cell type specific epigenome-wide association studies (EWAS) and expression quantitative trait methylation (eQTM) analyses reveal DNA methylation linked to asthma Epigenomics Collaborators: Vanderbilt University Medical Center, Henry Ford Health + Michigan State University Health Sciences +9 more AsthmaEpigeneticsMethylationRNA-seq
Dahl Labsites.google.com/view/andywdahl/people Dry lab~6 people Develops statistical genetics methods for single-cell RNA sequencing and biobank-based genetic studies. Targets complex-disease heterogeneity and patient subtypes with distinct causal biology. 17 papers since 2024 › Characterizing the genetic architecture of drug response using gene-context interaction methods Cell Genomics, 2024 Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression The American Journal of Human Genetics, 2024 Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines The American Journal of Human Genetics, 2024 Source: OpenAlex author A5110946393 7 platforms and techniques › Analyzes single-cell RNA sequencing Techniques gene-environment interaction, epistasis, clustering algorithms, statistical interaction tests, polygenic prediction, cell-type inference Source: lab pages Currently hiring › “We are seeking students and postdocs to join our statistical genetics research group.” Source: lab positions page No funding stated	Moderator Fri Oct 23 1:30 pm New Machine Learning Approaches in Genetics and Genomics Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Choice of phenotype scale is critical in biobank-based G×E tests Statistical Genetics and Genetic Epidemiology Collaborators: University of Pennsylvania Genome-wide association studyLarge-scale biobanksPolygenic risk score
Barreiro Labluis-barreirolab.org Wet + dry lab~16 people Combines RNA-seq and single-cell technologies with PBMC biobank, immunological assays and population genetics. Studies immune variation, infection responses and disease susceptibility across populations and primates. 34 papers since 2024 › β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus Nature Immunology, 2025 Microbial transmission in the social microbiome and host health and disease Cell, 2024 BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses Immunity, 2024 Source: OpenAlex author A5088435548 Funded by Chan Zuckerberg Initiative › Chan Zuckerberg Initiative · active Philanthropic science funding from the Chan Zuckerberg Initiative. “Our lab started a collaborative network with several PIs from South America, which was recently funded by the Chan Zuckerberg Initiative.” Source: lab pages 6 platforms and techniques › Runs RNA-seq Techniques Cell culture and immunological assays, Experimental evolution, iPSC-derived macrophages, In-vitro immunological assays, Quantitative trait loci mapping Source: lab pages Currently hiring › “We have two openings at the moment.” Source: lab positions page	Symposium Fri Oct 23 8:50 am The genomic architecture of immune variation across populations Host-Pathogen Coevolution: Shaping Genetic Diversity and Disease Resistance
Center for Personalized Therapeuticscpt.uchicago.edu/people-2-2 Wet lab~18 people Evaluates pharmacogenomic markers and genetic data in clinical trials. Supports personalized chemotherapy, medication decisions and patient care. Funded by National Institutes of Health (NIH), University of Chicago Biological Sciences Division +1 more › National Institutes of Health (NIH), Clinical Pharmacology and Pharmacogenomics (CCPP) Training Program · active “The Clinical Pharmacology and Pharmacogenomics (CCPP) Training Program is sponsored by the National Institutes of Health (NIH)” University of Chicago Biological Sciences Division, Clinical Pharmacology and Pharmacogenomics (CCPP) Training Program · active “The Clinical Pharmacology and Pharmacogenomics (CCPP) Training Program is sponsored by the National Institutes of Health (NIH), University of Chicago Biological Sciences Division” University of Chicago Cancer Research Foundation Women’s Board, Clinical Pharmacology and Pharmacogenomics (CCPP) Training Program · active “and the University of Chicago Cancer Research Foundation Women’s Board” Source: lab pages 5 platforms and techniques › Analyzes Genomic Prescribing System (GPS) Techniques Pharmacogenomic testing, Genotyping, Clinical trials, Clinical decision support Source: lab pages Currently hiring › “Join The Center of Personalized Therapeutics by applying to The University of Chicago’s Academic Jobs portal.” Source: lab positions page	Poster Thu Oct 22 4:15 pm Cisplatin-induced gene expression patterns reveal resistance and sensitivity insights across cancer types Pharmacogenomics Collaborators: University of Notre Dame CancerPharmacogenomicsTranslational studies and preclinical trialsTranscriptome Session Sat Oct 24 8:15 am Beyond the Blueprint: GENE-ius Interactive Strategies for Engagement
Im Labhakyimlab.org Dry lab~7 people Develops computational methods for RNA-seq, methylomic, proteomic and MRI data. Applies PrediXcan to UK Biobank, All of Us, TOPMed and MESA studies. 50 papers since 2024 › The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project Nature Genetics, 2025 A multi-tissue, splicing-based joint transcriptome-wide association study identifies susceptibility genes for breast cancer The American Journal of Human Genetics, 2024 Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits The American Journal of Human Genetics, 2024 Source: OpenAlex author A5051721434 Funded by NIH › NIH, Cloud Credit · 2017 “We are delighted to be awarded NIH Cloud Credit that will help us fund our cloud-based web applications and databases” Source: lab pages 12 platforms and techniques › Analyzes RNA-seq, Methylomic data, Proteomic data, MRI, 1000G genotypes Techniques PrediXcan, S-PrediXcan, MultiXcan, Fine-mapping, Machine learning, OmicKriging, TWAS Source: lab pages No openings posted	Poster Fri Oct 23 2:30 pm Shared and distinct transcriptional signatures of drug response across human cell types Pharmacogenomics PharmacogenomicsBioinformaticsMachine learningPrecision medicine
Institute for Population & Precision Healthipphlab.uchicago.edu/capabilities Wet lab~5 people Runs genome-wide SNP arrays, methylation assays, targeted sequencing, qPCR, MiSeq, HiSeq and Luminex assays on human biospecimens. Supports large-scale population health studies and precision medicine. 43 papers since 2024 › Genetic drivers of heterogeneity in type 2 diabetes pathophysiology Nature, 2024 DNA methylation correlates of chronological age in diverse human tissue types Epigenetics & Chromatin, 2024 The association of cigarette smoking with DNA methylation and gene expression in human tissue samples The American Journal of Human Genetics, 2024 Source: OpenAlex author A5081425275 Funded by NIH › NIH, Grants “It has been used in multiple NIH grants and publications.” Source: lab pages 14 platforms and techniques › Runs Genome-wide SNP genotyping arrays, Genome-wide methylation assays, Targeted DNA sequencing, qPCR, MiSeq, HiSeq, Luminex 200 Techniques PBMC and granulocyte separation, DNA and RNA extraction, Whole-exome and whole-genome sequencing, Bisulfite sequencing, Multiplex biomarker assays, Relative telomere length assay, Biobanking Source: lab pages No openings posted	Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Somatic mutation profile in unaffected colon tissue in Colorectal Carcinoma patients: Functional effect on Differential Gene expression and potential use in Precision Medicine. Cancer Collaborators: University of Chicago Research Bangladesh, College Station Medical Center GenomicsPrecision medicineSomatic variantsTranscriptome
Li Labthelilab.com Wet + dry lab~9 people Studies single-cell RNA-seq and chromatin-accessibility QTL data using computational biology and statistical genetics. Focuses on gene regulation, RNA splicing and splice-switching drugs in human disease. 137 papers since 2024 › A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis Bone Research, 2024 Advanced glycation end products and reactive oxygen species: uncovering the potential role of ferroptosis in diabetic complications Molecular Medicine, 2024 Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYs EClinicalMedicine, 2024 Source: OpenAlex author A5029768249 10 platforms and techniques › Analyzes single-cell RNA-seq, chromatin accessibility QTLs, multi-omics QTL colocalization Techniques computational biology, statistical genetics, experimental genomics, RNA splicing quantification, RNA splicing prediction, unproductive splicing analysis, alternative polyadenylation Source: lab pages Currently hiring › “We are seeking postdocs with a strong background in computational biology, statistical genetics, or related fields.” Source: lab positions page No funding stated	Talk Thu Oct 22 9:00 am Big models cheat, small models learn: Interpretable splice-site prediction with Angler Sequence Models Transforming Genetics and Genomics Artificial intelligenceDeep learningMachine learningRNA
Luca Lablucalab.org/people Dry lab~11 people Studies gene-environment interactions using gene expression, chromatin accessibility, scATAC-seq and RNA-seq data. Applies functional and evolutionary genomics to complex biomedical traits. 24 papers since 2024 › Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts The American Journal of Human Genetics, 2025 Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits Genome biology, 2025 Genotype × environment interactions in gene regulation and complex traits Nature Genetics, 2024 Source: OpenAlex author A5045777431 14 platforms and techniques › Analyzes scATAC-seq, RNA-seq, DNase-seq, Massively parallel reporter assays, Single-nucleus transcriptomics, Allele-specific expression Techniques Gene-environment interaction analysis, Functional genomics, Evolutionary genomics, eQTL analysis, DNase I footprinting, Host-microbiome interactions, Colocalization analysis, Neural-network modeling Source: lab pages No funding stated · No openings posted	Symposium Fri Oct 23 9:00 am Gene-environment in gene regulation mediates phenotypic plasticity over changing environments Emergence of Complex Traits at the Intersection of Genomics, Exposomic, and Time
Nobrega Labnobregalab.uchicago.edu Wet + dry lab~6 people Studies gene regulation using zebrafish transgenic reporter assays, mouse hearts, RNA-Seq and ChIP-Seq. Targets enhancers and regulatory variation in heart development, asthma and diabetes. 15 papers since 2024 › Effect of ultra-processed food consumption on male reproductive and metabolic health Cell Metabolism, 2025 Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring Nature Communications, 2024 Dietary macronutrient composition impacts gene regulation in adipose tissue Communications Biology, 2024 Source: OpenAlex author A5085696863 11 platforms and techniques › Runs BAC-based enhancer trapping, zebrafish transgenic reporter assays, RNA-Seq, ChIP-Seq, mouse transgenic reporter assays, ATAC-seq Techniques CRISPR/Cas9, comparative genomics, protein-DNA binding localization, mouse models, gene regulatory networks Source: lab pages No funding stated · No openings posted	Talk Fri Oct 23 2:15 pm Integrating computational genetics and functional genomics reveals palmitoylation as a therapeutically targetable pathway in asthma Multi-Omics Perspectives on Immune Regulation, Adaptation, and Inflammatory Disease Collaborators: First Affiliated Hospital of Kunming Medical University, Cornell University +1 more AsthmaExpression quantitative trait lociGenome editing/CRISPRStatistical genetics
Novembre Labjnpopgen.org/team Dry lab~6 people Develops computational tools for large-scale genomic, haplotype, and low-coverage ancient human DNA data. Studies human genetic variation, heritable disease traits, and evolutionary processes. 17 papers since 2024 › Reduced cyclin D3 expression in erythroid cells protects against malaria Nature, 2026 Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance bioRxiv (Cold Spring Harbor Laboratory), 2025 Study design and the sampling of deleterious rare variants in biobank-scale datasets bioRxiv (Cold Spring Harbor Laboratory), 2024 Source: OpenAlex author A5073718055 Funded by NIH › NIH, Extending Tools for Visualization of Geographic Structure in Population Genomic Data · 4/19 “Our NIH grant proposal on ‘Extending Tools for Visualization of Geographic Structure in Population Genomic Data’ has been awarded.” Source: lab pages 6 platforms and techniques › Techniques Population structure inference, Haplotype-based population-genetic inference, GWAS population-structure correction, Ancestry inference, EEMS, Runs-of-homozygosity analysis Source: lab pages No openings posted	Talk Wed Oct 21 11:45 am Understanding genetic and environmental complexity in phenotypic resemblance across relatedness in population-scale data Mapping Genetic Relatedness at Biobank Scale: Uncovering Hidden Signal from Rare Variants to Parent-of-Origin Effects Complex traitsHeritabilityLarge-scale biobanks
Pott Labpott-lab.uchicago.edu/people-2 Wet + dry lab~8 people Develops scNOMe-seq, scATAC-seq and PacBio-based single-molecule assays, plus organoid and CRISPR systems. Studies gene regulation in IBD, atrial fibrillation and human tissues. 6 papers since 2024 › Cell-type-specific eQTLs underlie the genetic architecture of complex traits Nature, 2026 Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients Nature Communications, 2025 Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn’s disease medRxiv, 2024 Source: OpenAlex author A5008444160 Funded by NIGMS, NHGRI +3 more › NIGMS, R35/MIRA · active “This work is supported by an R35/MIRA from NIGMS” NHGRI, R21 · active “and an R21 from NHGRI” Helmsley Trust, Gut Cell Atlas grant · active “This work on this project is supported by a Gut Cell Atlas grant from the Helmsley Trust” +2 more on the lab page Source: lab pages 9 platforms and techniques › Works with scNOMe-seq, scATAC-seq, PacBio, Drop-seq/DroNc-seq, 10x v2/3 chemistry Techniques Organoid-based cell culture, CRISPR-based perturbation experiments, Long-read sequencing, Single-molecule epigenetic assays Source: lab pages Currently hiring › “We are looking for several postdoctoral researchers with interest in gene regulation, single-cell and single-molecule genomics, and/or complex diseases.” Source: lab positions page	Talk Thu Oct 22 9:30 am Dissecting genetic effects on gene regulatory mechanisms with single-molecule footprinting New Adventures in Molecular Trait Mapping ChromatinLong-read sequencingStatistical geneticsGene regulation
SIMONS Labyuvalsimons.org Dry lab~3 people Studies human complex traits with population and quantitative genetics using GWAS and genomic datasets. Focuses on evolution, genetic architecture, mutation load and speciation. 14 papers since 2024 › Specificity, length and luck drive gene rankings in association studies Nature, 2025 Simple scaling laws control the genetic architectures of human complex traits PLoS Biology, 2025 Characterizing selection on complex traits through conditional frequency spectra Genetics, 2024 Source: OpenAlex author A5007114247 6 platforms and techniques › Techniques population genetics, quantitative genetics, statistical inference, order statistics, GWAS interpretation, ancestral haplotype reconstruction Source: lab pages No funding stated · No openings posted	Poster Thu Oct 22 4:15 pm The great human mutagenesis experiment Evolutionary and Population Genetics Identification of disease genesPopulation geneticsStatistical geneticsRare variants
Zhang Labzhanglaboratory.org/team Wet + dry lab~11 people Studies cortical neurogenesis and RNA isoforms using single-cell and spatial transcriptomic data, iPSC-derived organoids and neurons. Targets mechanisms and therapies for neurodevelopmental disorders. 11 papers since 2024 › Single-Cell RNA Sequencing Reveals the Spatial Heterogeneity and Functional Alteration of Endothelial Cells in Chronic Hepatitis B Infection International Journal of Molecular Sciences, 2024 Naked-Eye LAMP Assay of M. tuberculosis in Sputum by In Situ Au Nanoprobe Identification: For the In Vitro Diagnostics of Tuberculosis ACS Infectious Diseases, 2024 Splice-switching antisense oligonucleotides for pediatric neurological disorders Frontiers in Molecular Neuroscience, 2024 Source: OpenAlex author A5039643118 Funded by Simons Foundation Autism Research Initiative, NIGMS +2 more › Simons Foundation Autism Research Initiative · 2025 “The Zhang lab received continued support from the Simons Foundation Autism Research Initiative.” NIGMS, MIRA award · 2024 “Our group is awarded a MIRA award to investigate protein-RNA interaction and alternative splicing. Thank you NIGMS for the continued support!” NIMH, R01 · 2023 The NIH's standard multi-year research project grant. “Our Lab is awarded its first R01. Thanks to NIMH for supporting our research!” +1 more on the lab page Source: lab pages 9 platforms and techniques › Works with single-cell RNA sequencing, single-cell long-read sequencing, spatial transcriptomics, PIE-seq Techniques iPSC-derived cerebral organoids, iPSC-derived neurons, splice-switching antisense oligonucleotides, RNA deaminase-based recording, genetic approaches Source: lab pages Currently hiring › “We are hiring - please drop us an email if you're interested in investigating brain development and disorders.” Source: lab positions page	Talk Sat Oct 24 8:30 am Transcriptome-wide Mendelian randomization reveals widespread antagonistic pleiotropy between reproductive fitness and complex diseases The Selection Paradox: Why Disease Variants Persist Evolutionary geneticsMendelian randomizationComplex traits
7 more presenters — research group not yet identified

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