ASHG 2026 · Hospital & health system

St. Jude Children's Research Hospital at ASHG 2026

Name: ASHG 2026 Annual Meeting
Start: 2026-10-20
End: 2026-10-24
Location: Montréal

Memphis, Tennessee

St. Jude Children's Research Hospital at ASHG 2026 in Montréal: 7 presentations (6 posters, 1 featured symposium); 6 research groups; Booth 211.

presentations on the program

research groups identified

sessions invited to or moderated

211

exhibit booth

Explore everyone at ASHG 2026 →

Organization	ASHG 2026 Attendance
St. Jude Children's Research Hospital Memphis, Tennessee	4 PIs · 2 Postdocs · 2 Staff Scientists · 1 PhD Student
	Booth Exhibiting at Booth 211 Wed, Oct 219:45am–4:30pmThu, Oct 229:45am–1:30pmFri, Oct 239:45am–4:30pm
Mefford Labstjude.org/research/labs/mefford-lab.html Wet + dry lab~11 people Uses short-read and long-read genome sequencing, genome-wide methylation arrays and patient-derived organoids. Studies genetic and epigenetic causes of pediatric epilepsy for precision therapies. 28 papers since 2024 › Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy New England Journal of Medicine, 2025 Developmental and epileptic encephalopathies Nature Reviews Disease Primers, 2024 Diagnostic utility of DNA methylation analysis in genetically unsolved pediatric epilepsies and CHD2 episignature refinement Nature Communications, 2024 Source: OpenAlex author A5033872267 7 platforms and techniques › Analyzes short-read genome sequencing, long-read genome sequencing, genome-wide methylation array analysis, transcriptome analysis Techniques patient-derived organoid systems, patient-derived cell lines, genome-wide methylation analysis Source: lab pages No funding stated · No openings posted	Poster Wed Oct 21 2:30 pm Pathogenic GNAI1 variants disrupt GPCR signaling and alter neurodevelopment in human iPSC-derived neurons and cortical organoids Molecular Effects of Genetic Variation Collaborators: Temple University, University of Otago +1 more EpilepsyMolecular pathophysiologyNeurodevelopmentalSingle-cell Poster Fri Oct 23 2:30 pm Improving missense variant interpretation through re-evaluation of ACMG criteria and incorporation of methylation analysis in CHD2-NDD Genetic, Genomic, and Epigenomic Resources and Databases Collaborators: University of Washington Variant interpretationNeurogeneticsNeurodevelopmentalEpigenetics Attendee in“I'm excited to help lead the society alongside a superb group of 💪 women 👩‍🔬 the next few years - see you at #ASHG26 in Montreal!”
Genetics Groupstjudecab.github.io/Genetics_team Dry lab~3 people Analyzes WGS, WES, genotype and RNA-seq data with computational genetics methods. Studies pediatric cancer, rare nonmalignant blood diseases and neurodegenerative disorders. 9 papers since 2024 › Integrated drivers of basal and acute immunity in diverse human populations Cell Reports Medicine, 2026 The genomic basis of childhood T-lineage acute lymphoblastic leukaemia Nature, 2024 Genetic Associations With an Amyotrophic Lateral Sclerosis Reversal Phenotype Neurology, 2024 Source: OpenAlex author A5025625415 Funded by National Cancer Institute at National Institute of Health › National Cancer Institute at National Institute of Health · active “We are grateful for funding from the National Cancer Institute at National Institute of Health” Source: lab pages 10 platforms and techniques › Analyzes WGS, WES, Genotype, RNA-seq Techniques computational genetics/genomics methods, applied statistical analyses, machine learning, genome-wide association meta-analysis, whole-genome sequencing, exome sequencing Source: lab pages Currently hiring › “Open positions” Source: lab positions page	Poster Wed Oct 21 2:30 pm AI-enabled fine-mapping of GWAS signal from age at onset in sporadic amyotrophic lateral sclerosis identifies a regulatory variant at PDE4D that creates a neuronal NF-Y CCAAT-box enhancer Artificial Intelligence and Machine Learning Genome-wide association studyExpression quantitative trait lociArtificial intelligenceNeurodegeneration Poster Fri Oct 23 2:30 pm Integrating AI-assisted hypothesis generation with survival GWAS nominates candidate genetic modifiers of ALS survival Statistical Genetics and Genetic Epidemiology Artificial intelligenceNeurogeneticsGenome-wide association studyNeurodegeneration
Savic Labstjude.org/research/labs/savic-lab/savic-lab-team.html Wet + dry lab~7 people Uses massively parallel reporter assays, CRISPR-based functional screening, and epigenomic and transcriptomic profiling in childhood leukemia. Studies enhancer regulation, drug response and resistance. 11 papers since 2024 › The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity Journal of Clinical Investigation, 2025 Differentiation-dependent EBF1 activity determines CD22 transcription and leukemia sensitivity to inotuzumab ozogamicin Blood, 2025 Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment Nature Communications, 2024 Source: OpenAlex author A5090208284 8 platforms and techniques › Runs Massively parallel reporter assays, CRISPR-based functional screening approaches Techniques Functional genomics, Genome engineering, Epigenomic and transcriptomic profiling, Primary leukemia cells, Chromatin profiling, Patient-derived genomic datasets Source: lab pages No funding stated · No openings posted	Moderator Thu Oct 22 11:00 am Cancer Susceptibility: Germline Effects on Risk, Mechanisms, and Mutations Symposium Fri Oct 23 8:35 am Massively parallel functional investigation of the impact of regulatory variants on glucocorticoid response Pharmacogenomics: Moving Beyond Gene-Drug Pairs
Wu Labstjude.org/research/labs/wu-lab-gang.html Dry lab~3 people Analyzes whole-genome sequencing and targeted long-read bisulfite-sequencing data with bioinformatics and multi-omics integration. Studies disease-predisposition variants, neurodegeneration and genome instability. 99 papers since 2024 › Double‐Network Slide‐Ring Topological Hydrogel Fibers: Fabrication and Sensor Application Small, 2025 Turbid image tackling framework towards underwater concrete bridge detection based on distance control and deep learning Advanced Engineering Informatics, 2024 Time-variant seismic resilience of reinforced concrete buildings subjected to spatiotemporal random deterioration Engineering Structures, 2024 Source: OpenAlex author A5100717613 9 platforms and techniques › Analyzes whole-genome sequencing, targeted long-read bisulfite sequencing, single-cell gene expression Techniques multi-omics integration, machine learning, rare variant burden analysis, synthetic control cohorts, bioinformatics pipelines, genomic rearrangement modeling Source: lab pages No funding stated · No openings posted	Poster Wed Oct 21 2:30 pm Prioritizing Novel Predisposition Genes for Orofacial Cleft Through Rare Variant Burden Analysis Using Kids First Sequencing Data and External Controls Statistical Genetics and Genetic Epidemiology Collaborators: Mayo Clinic Rare variantsBioinformatics
Division of Cancer Predispositionstjude.org/research/departments/oncology/cancer-predisposition.html Wet + dry lab~21 people Studies hereditary cancer predisposition using genetic testing, mouse models and bioinformatics analysis of pediatric cancer genomes. Supports surveillance and family-centered care. 113 papers since 2024 › Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study The Lancet Oncology, 2024 Clinical Updates and Surveillance Recommendations for DNA Replication Repair Deficiency Syndromes in Children and Young Adults Clinical Cancer Research, 2024 The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study The Lancet Oncology, 2024 Source: OpenAlex author A5025442855 Funded by National Cancer Institute, ALSAC +1 more › National Cancer Institute, Grants CA216354 and CA216391 “The research was funded in part by National Cancer Institute grants (CA216354, CA216391) and ALSAC” ALSAC “The research was funded in part by National Cancer Institute grants (CA216354, CA216391) and ALSAC” National Cancer Institute, Grant CA241452 “funded in part by a grant (CA241452) from the National Cancer Institute and ALSAC” Source: lab pages 8 platforms and techniques › Analyzes Whole-genome sequencing, Whole-exome sequencing, RNA sequencing Techniques Mouse models, Functional genomics, Bioinformatics workflows, Integrative multi-omics analysis, Genetic counseling and testing Source: lab pages Currently hiring › “We seek a highly motivated, faculty-level investigator (clinician scientist or clinician track) with training in hematology and oncology or clinical genetics” Source: lab positions page	Attendee in“As part of ASHG program committee, I look forward to reviewing cutting-edge science from your projects.”
Epidemiology and Cancer Control Works in cancer genetics and population genetics.	Poster Thu Oct 22 4:15 pm Multi-ancestry genetic analysis identifies novel contributors to endocrine dysfunction in childhood cancer survivors: a report from the St. Jude Lifetime Cohort Study Cancer Endocrine systemGenetic epidemiologyGenome-wide association studyCancer

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