ASHG 2026 · Hospital & health system

Nationwide Children's Hospital at ASHG 2026

Name: ASHG 2026 Annual Meeting
Start: 2026-10-20
End: 2026-10-24
Location: Montréal

Columbus, Ohio

Nationwide Children's Hospital at ASHG 2026 in Montréal: 10 presentations (8 posters, 1 featured symposium, 1 lightning talk); 6 research groups.

presentations on the program

research groups identified

Reviewers’ Choice abstracts

Explore everyone at ASHG 2026 →

Organization	ASHG 2026 Attendance
Nationwide Children's Hospital Columbus, Ohio	3 Staff Scientists · 2 Faculty · 1 Clinician · 1 PI
Artomov Labnationwidechildrens.org/specialties/institute-for-genomic-medicine/research-labs/artomov-lab Dry lab~6 people Analyzes genome and exome sequencing plus clinical, genetic and electronic healthcare records from major biobanks. Develops computational methods for disease-gene discovery and risk prediction. 35 papers since 2024 › Germline cancer susceptibility in individuals with melanoma Journal of the American Academy of Dermatology, 2024 Making sense of missense: challenges and opportunities in variant pathogenicity prediction Disease Models & Mechanisms, 2024 Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer The American Journal of Human Genetics, 2024 Source: OpenAlex author A5082319199 Funded by National Institutes of Health (NIH) › National Institutes of Health (NIH), Environmental Influences on Child Health Outcomes (ECHO) · 2023 “awarded $17.7 million from the National Institutes of Health (NIH) to join a national consortium” Source: lab pages 14 platforms and techniques › Analyzes Genome sequencing, Exome sequencing, DNA sequencing, Gene expression data, Electronic healthcare records, Genotyping data, Secure matched-control platform Techniques Systems genetics, Statistical models for health outcomes, Genome-wide association studies, Gene prioritization, Variant interpretation, Survival analysis, Multifactorial risk models Source: lab pages No openings posted	Talk Wed Oct 21 1:59 pm Polygenic risk stratification identifies hypothyroid patients with skin cancer risk comparable to family history and UV-related risk factors Advancing Precision Oncology with AI, Functional Genomics, and Multi-Omics: From Risk Prediction to Tumor Evolution and Therapeutic Discovery Collaborators: The Ohio State University, Institute for Molecular Medicine Finland +2 more CancerComplex traitsGene environment interactionPolygenic risk score Poster Wed Oct 21 2:30 pm Widespread heterogeneity in polygenic risk score effects across clinical histories in about 1 million individuals from UK Biobank and FinnGen Complex Traits and Polygenic Disorders Collaborators: Institute for Molecular Medicine Finland, The Ohio State University +3 more Complex diseasesElectronic health recordsLarge-scale biobanksPolygenic risk score Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Polygenic risk stratification identifies hypothyroid patients with skin cancer risk comparable to family history and UV-related risk factors Cancer Collaborators: The Ohio State University, Institute for Molecular Medicine Finland +2 more CancerComplex traitsGene environment interactionPolygenic risk score Poster Fri Oct 23 2:30 pm BMI-restricted ascertainment inflates genetic associations between anorexia nervosa and body mass index Complex Traits and Polygenic Disorders Collaborators: The Ohio State University, Massachusetts General Hospital +1 more Electronic health recordsPolygenic risk scorePopulation geneticsPsychiatric genetics
Steve and Cindy Rasmussen Institute for Genomic Medicinenationwidechildrens.org/specialties/institute-for-genomic-medicine/faculty Wet + dry lab~51 people Generates and analyzes NGS data, including whole-genome, exome, RNA/miRNA and 10x single-cell/spatial workflows. Translates genomic results into pediatric diagnosis and treatment through translational research. Funded by Nationwide Foundation › Nationwide Foundation, Pediatric Innovation Fund · since 2014 “Since 2014, Nationwide Foundation has contributed $80 million to the fund.” Source: lab pages 16 platforms and techniques › Runs Illumina NovaSeq6000, Illumina NextSeq2000, PacBio Sequel IIe, PacBio Revio, 10x Genomics Chromium X, 10x Genomics Single Cell ATAC, 10x Genomics Visium Spatial Gene Expression, NanoString GeoMx Digital Spatial Profiler Techniques Whole-genome sequencing, Whole-exome sequencing, RNA/miRNA sequencing, Paired tumor-normal somatic variant detection, PacBio HiFi, Iso-Seq, Kinnex single-cell sequencing, CSF liquid biopsy using cfDNA/RNA Source: lab pages Currently hiring › “The team at the Institute for Genomic Medicine is growing. Click the link below to view current job listings” Source: lab positions page	Poster Wed Oct 21 2:30 pm Establishing a Translational Framework for Inherited (WS, SVAS, Cutis Laxa) and Acquired Elastinopathies via Codon Optimization and Non-Viral Gene Therapy Genetic Therapies and Precision Medicine Collaborators: The Ohio State University Gene therapyDevelopment Poster Fri Oct 23 2:30 pm Translational research genomics guides diagnosis and gene therapy for inherited neuromuscular disorders Genetic Therapies and Precision Medicine Collaborators: The Ohio State University Alternative splicingGene therapyLong-read sequencingMulti-omics
Biomedical Interpretation & Training (BIT) Teamnationwidechildrens.org/specialties/institute-for-genomic-medicine/biomedical-informatics-and-training-team Dry lab~6 people Analyzes whole-genome, exome, RNA-seq, long-read and optical genome-mapping data. Develops variant-interpretation tools for rare diseases, epilepsy and pediatric cancers. 10 platforms and techniques › Analyzes WGS, WES, RNA-seq, long-read sequencing, optical genome mapping Techniques variant calling, variant prioritization, variant interpretation, epigenetic profiling, gene-phenotype association discovery Source: lab pages No funding stated · No openings posted	Poster Wed Oct 21 2:30 pm Variable Concordance Between Splice Prediction Tools AlphaGenome and SpliceAI-10k and RNA-Seq Evidence Artificial Intelligence and Machine Learning Alternative splicingArtificial intelligenceRNA-seqVariant interpretation in“This year at ASHG 2026, I'll be presenting a systematic evaluation of concordance and discordance between splice prediction tools (AlphaGenome and…”
Genetic and Genomic Medicinenationwidechildrens.org/specialties/genetic-and-genomic-medicine ~45 people Uses genetic and genomic information to diagnose and treat hereditary disorders. Research partners include the Institute for Genomic Medicine and the Center for Gene Therapy. 16 papers since 2024 › The Clinical Genome Resource (ClinGen): Advancing genomic knowledge through global curation Genetics in Medicine, 2024 Long-read genome sequencing resolves complex genomic rearrangements in rare genetic syndromes npj Genomic Medicine, 2024 Implementing evidence-based assertions of clinical actionability in the context of secondary findings: Updates from the ClinGen Actionability Working Group Genetics in Medicine, 2024 Source: OpenAlex author A5110636074 Funded by Ohio Department of Health › Ohio Department of Health, Regional Genetics Center of the State of Ohio, Region IV · active “Clinical services are supported partly by the Ohio Department of Health as a Regional Genetics Center of the State of Ohio, Region IV.” Source: lab pages 1 platform and technique › Techniques genetic testing Source: lab pages No openings posted	Symposium Wed Oct 21 8:15 am Introduction Adult DNA-Based Population Genomic Screening: Moving from Pilots to Practice
Institute for Genomic Medicinenationwidechildrens.org/specialties/institute-for-genomic-medicine/faculty Wet + dry lab~51 people Generates and analyzes NGS data, including whole-genome, exome, RNA/miRNA and 10x single-cell/spatial workflows. Translates genomic results into pediatric diagnosis and treatment through translational research. Funded by Nationwide Foundation › Nationwide Foundation, Pediatric Innovation Fund · since 2014 “Since 2014, Nationwide Foundation has contributed $80 million to the fund.” Source: lab pages 16 platforms and techniques › Runs Illumina NovaSeq6000, Illumina NextSeq2000, PacBio Sequel IIe, PacBio Revio, 10x Genomics Chromium X, 10x Genomics Single Cell ATAC, 10x Genomics Visium Spatial Gene Expression, NanoString GeoMx Digital Spatial Profiler Techniques Whole-genome sequencing, Whole-exome sequencing, RNA/miRNA sequencing, Paired tumor-normal somatic variant detection, PacBio HiFi, Iso-Seq, Kinnex single-cell sequencing, CSF liquid biopsy using cfDNA/RNA Source: lab pages Currently hiring › “The team at the Institute for Genomic Medicine is growing. Click the link below to view current job listings” Source: lab positions page	Poster Thu Oct 22 4:15 pm Phenotypic consequences of BAZ1B loss in humans and mice and their relationship to Williams Syndrome Mendelian Phenotypes Collaborators: National Heart, Lung, and Blood Institute, University of Virginia +8 more Characterization of syndromesDevelopmentGastrointestinal systemModel organisms
Wagner Labnationwidechildrens.org/specialties/institute-for-genomic-medicine/research-labs/wagner-lab/wagner-lab-staff Dry lab~8 people Develops computational tools and standards for clinical interpretation of patient genomes and genomic variants. Collaborates with ClinGen, GA4GH and VICC to support precision medicine. Funded by National Human Genome Research Institute, National Cancer Institute › National Human Genome Research Institute, K99/R00 · active “Dr. Wagner serves as PI of a prestigious K99/R00 grant from the National Human Genome Research Institute to support this ongoing work.” National Cancer Institute, NRSA Postdoctoral Fellowship (F32) “Dr. Wagner was also awarded an NRSA Postdoctoral Fellowship (F32) from the National Cancer Institute.” Source: lab pages 4 platforms and techniques › Techniques Clinical variant interpretation, Formal modeling and schema development, Machine learning in clinical medicine, Genomic variant analysis and interpretation Source: lab pages Currently hiring › “The team at the Institute for Genomic Medicine is growing. Click the link below to view current job listings” Source: lab positions page	Poster Fri Oct 23 2:30 pm From Local Classifications to ClinVar at Scale: Submitting the Largest Pediatric Somatic Variant Classification Dataset Using Open-Source Workflows Cancer Collaborators: The Ohio State University BioinformaticsCancerDatabasesGenomics

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