ASHG 2026 · Gov/NGO

National Cancer Institute at ASHG 2026

Name: ASHG 2026 Annual Meeting
Start: 2026-10-20
End: 2026-10-24
Location: Montréal

Bethesda, Maryland

National Cancer Institute at ASHG 2026 in Montréal: 17 presentations (10 posters, 6 platform talks, 1 lightning talk); 11 research groups.

presentations on the program

research groups identified

Reviewers’ Choice abstracts

Explore everyone at ASHG 2026 →

Organization	ASHG 2026 Attendance
National Cancer Institute Bethesda, Maryland	8 Postdocs · 5 PIs · 2 Staff Scientists · 1 Faculty
Choi Laboratorydceg.cancer.gov/about/organization/tdrp/ltg/choi-lab Wet + dry lab~6 people Studies lung-cancer susceptibility using GWAS, single-cell transcriptomic and epigenomic profiling, chromatin interaction analyses and CRISPR. Applies findings to functional mechanisms in smokers and never-smokers. 26 papers since 2024 › The mutagenic forces shaping the genomes of lung cancer in never smokers Nature, 2025 Genome-wide association study identifies high-impact susceptibility loci for HCC in North America Hepatology, 2024 Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes Nature Communications, 2024 Source: OpenAlex author A5013186571 Funded by National Cancer Institute, NCI Intramural Research Program › NCI Intramural Research Program, CCR-DCEG Collaborative Award · 2022 “Chongyi Chen (CCR), [name], M.S., [name], M.D., Ph.D., and [name], Ph.D.” National Cancer Institute, NCI Director’s Intramural Innovation Award Program · 2021 “[name], M.S. – “Single-cell eQTL profiling of normal lung in Asian never-smokers” Source: lab pages 10 platforms and techniques › Runs Massively parallel reporter assays, Chromatin interaction profiling, Single-cell sequencing, Hi-C, Long-read sequencing Techniques CRISPR, Induced pluripotent stem cell-derived lung cells, Genome-wide association studies, Single-cell splice-QTL, Cell-based systems Source: lab pages Currently hiring › “[name], M.S. ... is seeking to recruit a postdoctoral fellow to join the [name] Research Laboratory.” Source: lab positions page	Poster Wed Oct 21 2:30 pm Chromatin interactions from lung cells identify smoking-related cancer susceptibility genes Cancer Collaborators: UNM Comprehensive Cancer Center Complex diseasesGene environment interactionEtiologyGenome-wide association study Talk Thu Oct 22 11:45 am Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression Pivoting from Gene-Level Analyses to Isoform-Resolved Biology Collaborators: University of Pennsylvania, Yonsei University +5 more Alternative splicingLong-read sequencingTranscriptomeSingle-cell Talk Thu Oct 22 11:45 am Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology Cancer Susceptibility: Germline Effects on Risk, Mechanisms, and Mutations Collaborators: Frederick National Laboratory for Cancer Research, University of Pennsylvania +5 more Single-cellExpression quantitative trait lociGenome-wide association studyCancer
Amundadottir Laboratorydceg.cancer.gov/about/organization/tdrp/ltg/amundadottir-lab Wet + dry lab~6 people Maps pancreatic-cancer risk loci using GWAS, WGS, eQTL, TWAS and CRISPR-based analyses. Studies inherited variants in pancreatic tissue through PanScan. 98 papers since 2024 › A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice Gut, 2025 Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma Gut, 2025 High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility The American Journal of Human Genetics, 2024 Source: OpenAlex author A5042493218 Funded by CCR-DCEG, › , K99/R00 Pathway to Independence grant · active “received a K99/R00 Pathway to Independence grant focused on improving in vitro pancreas cell models” CCR-DCEG, FLEX Award · 2021 “have received the 2021 CCR-DCEG FLEX award” Source: lab pages 14 platforms and techniques › Analyzes GWAS, Whole-genome sequencing (WGS), eQTL analyses, TWAS, CRISPR-based regulatory-element analysis, DNA methylation, Open chromatin, Three-dimensional chromatin interactions Techniques Fine-mapping, GWAS imputation, CRISPR regulatory-element analysis, Targeted functional analyses, Systems biology, In vitro pancreas cell models Source: lab pages No openings posted	Talk Wed Oct 21 2:27 pm Functional characterization of the multi-cancer risk locus 5p15.33 in normal pancreas cell types under endoplasmic reticulum stress Advancing Precision Oncology with AI, Functional Genomics, and Multi-Omics: From Risk Prediction to Tumor Evolution and Therapeutic Discovery Collaborators: Mayo Clinic, Sidney Kimmel Comprehensive Cancer Center +2 more CancerGenome-wide association studyGenomicsMassively parallel sequencing Poster Fri Oct 23 2:30 pm Functional characterization of a pancreatic cancer GWAS signal implicates PDX1 as a stress-buffering regulator in the exocrine pancreas Cancer Gene regulationCancerSusceptibility locusSingle-cell Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Functional characterization of the multi-cancer risk locus 5p15.33 in normal pancreas cell types under endoplasmic reticulum stress. Cancer Collaborators: Mayo Clinic, Sidney Kimmel Comprehensive Cancer Center +3 more CancerGenome-wide association studyGenomicsMassively parallel sequencing
Clinical Genetics Branchdceg.cancer.gov/about/organization/tdrp/cgb Dry lab~41 people Analyzes EHR-linked exome sequencing, whole-genome sequences and deep targeted sequencing in cancer studies. Supports cancer-risk prediction and prevention with Geisinger and the KPNC-NCI HPV cohort. 21 papers since 2024 › COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2 npj Vaccines, 2026 Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma Nature Communications, 2025 Canadian cancer trials group LY .17: A randomized phase II study evaluating novel salvage therapy pre‐autologous stem cell transplant in relapsed/refractory diffuse large B‐cell lymphoma—outcome of rituximab‐dose‐intensive cyclophosphamide, etoposide, cisplatin (R‐ DICEP ) versus R‐ GDP British Journal of Haematology, 2024 Source: OpenAlex author A5068947490 12 platforms and techniques › Analyzes electronic health record-linked exome sequencing, electronic health record-linked genome sequencing, whole-genome sequencing, deep targeted sequencing, HPV genotyping assays, HPV methylation Techniques next-generation sequencing of NF1-associated tumors, telomere length measurement, biomarker discovery and evaluation, population-based risk prediction, Automated Germline Variant Pathogenicity, automated visual evaluation Source: lab pages Currently hiring › “Postdoctoral and clinical fellowship applications are accepted on a continuous basis.” Source: lab positions page No funding stated	Poster Fri Oct 23 2:30 pm Genotype-first characterization of PALB2-related cancer risk in two large biobanks Cancer Cancer syndromesGenetic epidemiologyLarge-scale biobanksExome/genome sequencing Poster Fri Oct 23 2:30 pm Six common variants in CHEK2: A genome-first approach to the UK Biobank and Geisinger MyCode cohorts Cancer CancerClinical geneticsGenotype-phenotype correlationsGenomics
Machiela Labgithub.com/machiela-lab Dry lab~5 people Analyzes genotype data, GWAS, UK Biobank electronic medical records, and DNA microarray data. Investigates mosaic chromosomal alterations and cancer risk. 90 papers since 2024 › Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions Nature Genetics, 2024 Genetic drivers and cellular selection of female mosaic X chromosome loss Nature, 2024 FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases Genome biology, 2024 Source: OpenAlex author A5071089674 Funded by NIH, NIH +2 more › NIH · active “This work is supported by NIH grant R01 HG006855” NIH · active “NIH grant R01 MH104964” NIH · active “NIH grant R01MH123451” +1 more on the lab page Source: lab pages 15 platforms and techniques › Analyzes UK Biobank electronic medical record data, UK Biobank DNA microarray data, Illumina GenCall, Affymetrix Axiom, 1000 Genomes Project reference haplotypes, GTEx Portal, PLCO GWAS summary statistics, LDlink Techniques genetic association studies, genome-wide association studies, mosaic chromosomal alteration detection, genotype imputation, time-to-event analyses, linkage disequilibrium workflows, genotype phasing Source: lab pages No openings posted	Poster Thu Oct 22 4:15 pm Mosaic chromosomal alterations are associated with epigenetic age acceleration and localized DNA methylation remodeling in PLCO Cancer Chromosomal abnormalitiesEpidemiologyEpigeneticsEpigenome-wide association studies Talk Fri Oct 23 11:00 am mCA Explorer: an interactive catalog of mosaic chromosomal alterations detected in large population-based genomic investigations New Methods for Detecting Clonal Hematopoiesis and Somatic Variation Across Scales Collaborators: Division of Cancer Epidemiology and Genetics Chromosomal abnormalitiesGenomicsLarge-scale biobanks
Biostatistics Branchdceg.cancer.gov/about/organization/tdrp/bb Dry lab~37 people Develops statistical methods for GWAS, next-generation sequencing, single-cell sequencing and electronic medical-record data. Applies them to cancer etiology, risk prediction and public-health studies. 103 papers since 2024 › Accommodating detection limits of multiple exposures in environmental mixture analyses: an overview of statistical approaches Environmental Health, 2024 An Updated Evaluation of Atrazine-Cancer Incidence Associations among Pesticide Applicators in the Agricultural Health Study Cohort Environmental Health Perspectives, 2024 The landscape of etiological patterns of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in Thailand International Journal of Cancer, 2024 Source: OpenAlex author A5039237147 12 platforms and techniques › Analyzes Genome-wide association studies (GWAS), Next-generation sequencing (NGS), Single-cell sequencing, Whole-genome sequencing, SNP arrays, Electronic medical records (EHR) Techniques Polygenic risk scores, Mutational signature analysis, Copy-number estimation, Record linkage, Machine learning, Joint longitudinal-survival modeling Source: lab pages Currently hiring › “Open positions for fellowships in the DCEG Biostatistics Branch.” Source: lab positions page No funding stated	Poster Thu Oct 22 4:15 pm Uncovering the Heritability of Longitudinal EHR Traits in the Presence of Informative Measurement Processes Statistical Genetics and Genetic Epidemiology Collaborators: Division of Cancer Epidemiology and Genetics Electronic health recordsGenetic epidemiologyGenome-wide association studyMethodology
Integrative Tumor Epidemiology Branchdceg.cancer.gov/about/organization/tdrp/iteb Wet + dry lab~42 people Analyzes whole-genome sequencing, whole-transcriptome, methylation, microbiome and tissue-profile data. Studies cancer etiology, progression and risk across breast, kidney and lung cancers. 88 papers since 2024 › Trends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010–2019 Cancer Discovery, 2025 Long-term cardiovascular disease risk after anthracycline and trastuzumab treatments in US breast cancer survivors JNCI Journal of the National Cancer Institute, 2024 Risk factors for breast cancer subtypes by race and ethnicity: a scoping review JNCI Journal of the National Cancer Institute, 2024 Source: OpenAlex author A5052880291 16 platforms and techniques › Works with whole-genome sequencing, deep target sequencing, whole-genome methylation, SNP arrays, whole transcriptome, immunohistochemistry staining, in situ hybridization staining, digital pathology Techniques molecular pathology, somatic genomics, germline genomics, histopathology, genome-wide association studies (GWAS), multi-omic analysis, computational pathoepidemiology, tissue profiling Source: lab pages Currently hiring › “Postdoctoral, predoctoral, and postbaccalaureate fellowship applications are accepted on a continuous basis.” Source: lab positions page No funding stated	Talk Fri Oct 23 11:00 am Genetic effects of common variants on RNA modifications in induced pluripotent stem cells RNA Unbound: New Regulatory Layers from Modifications to Circular RNA in Disease Collaborators: University of Michigan BioinformaticsExpression quantitative trait lociMethylationRNA
Integrative Tumor Epidemiology Branch (ITEB)dceg.cancer.gov/about/organization/tdrp/iteb/principal-investigators-iteb Wet + dry lab~23 people Analyzes whole-genome sequencing, whole-transcriptome, genome-wide methylation and microbiome data with tissue profiles. Studies cancer etiology and progression to inform prevention and clinical strategies. 13 platforms and techniques › Works with whole-genome sequencing, whole transcriptome, genome-wide methylation, microbiome data, deep target sequencing, SNP array analyses, immunohistochemistry/in situ hybridization staining, digital pathology Techniques molecular pathology, somatic and germline genomics, histopathology, genome-wide association studies (GWAS), genetic mosaicism Source: lab pages Currently hiring › “Postdoctoral, predoctoral, and postbaccalaureate fellowship applications are accepted on a continuous basis.” Source: lab positions page No funding stated	Poster Thu Oct 22 4:15 pm Integrated methylation and transcriptomic profiling identifies novel prognostic factors in skull-base chordoma Cancer Collaborators: Division of Cancer Epidemiology and Genetics, The University of Texas MD Anderson Cancer Center +3 more CancerMethylationMulti-omicsRNA-seq
Occupational and Environmental Epidemiology Branch (OEEB)dceg.cancer.gov/about/organization/tdrp/oeeb Dry lab~43 people Studies occupational and environmental exposures using GIS, GWAS, methylation and next-generation sequencing. Main uses are cancer-risk assessment and carcinogen identification. 46 papers since 2024 › Geographic variation of mutagenic exposures in kidney cancer genomes Nature, 2024 Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions Nature Genetics, 2024 Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis EBioMedicine, 2024 Source: OpenAlex author A5019866236 Funded by NCI, NIH Office of Research on Women’s Health › NCI, NCI Director’s Innovation Award “NCI Director’s Innovation Award” NIH Office of Research on Women’s Health, Co-Funding Award “NIH Office of Research on Women’s Health Co-Funding Award” Source: lab pages 14 platforms and techniques › Analyzes PLCO Atlas, metabolomics, gene expression, miRNA, microbiomics, methylation, genome-wide association studies (GWAS), next-generation sequencing Techniques geographic information systems, exposomics, exposure assessment, gene-environment interactions, molecular biomarker studies, case-control and prospective cohort designs Source: lab pages Currently hiring › “The Occupational and Environmental Epidemiology Branch (OEEB) of the NCI is seeking postdoctoral fellows” Source: lab positions page	Poster Wed Oct 21 2:30 pm LDscore: a scalable, Python 3-powered web platform for LD score regression analysis Genetic, Genomic, and Epigenomic Resources and Databases Collaborators: University of Chinese Academy of Sciences Linkage disequilibriumBioinformaticsGenome-wide association studyHeritability in“Please find me at ... ASHG (Montreal, Oct.)”
Trans-Divisional Research Program (TDRP)dceg.cancer.gov/about/organization/tdrp Dry lab~7 people Coordinates cancer epidemiology, genetics and prevention through the Connect cohort, EHRs, biospecimens, EpiSphere and GWAS. Supports precision prevention and early detection. 207 papers since 2024 › Translational genomics of osteoarthritis in 1,962,069 individuals Nature, 2025 Functional evaluation and clinical classification of BRCA2 variants Nature, 2025 Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function Nature Medicine, 2025 Source: OpenAlex author A5056487867 Funded by NIH Intramural Research Program › NIH Intramural Research Program · active “Connect is supported by the NIH Intramural Research Program.” Source: lab pages 8 platforms and techniques › Analyzes EpiSphere, FeatureScape, Serverless OpenHealth, Connect for Cancer Prevention Data Platform Techniques GWAS, Genomic, epigenomic and transcriptomic analysis, Tumor molecular profiling, Exposure tracking and sensors Source: lab pages Currently hiring › “Postdoctoral, predoctoral, and postbaccalaureate fellowship applications are accepted on a continuous basis.” Source: lab positions page	Poster Fri Oct 23 2:30 pm Polygenic risk for lung cancer is amplified by current smoking: a comparison of two PGS in the PLCO cohort Cancer Polygenic risk scoreGene environment interactionCancer
Zhang's Research Teamdceg.cancer.gov/about/staff-directory/zhang-haoyu Dry lab Develops scalable statistical methods for UK Biobank, All of Us and 23andMe genetic data. Translates findings to clinical settings for prevention and therapeutic strategies. 96 papers since 2024 › Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction Nature Genetics, 2024 An ensemble penalized regression method for multi-ancestry polygenic risk prediction Nature Communications, 2024 Abscopal effect: from a rare phenomenon to a new frontier in cancer therapy Biomarker Research, 2024 Source: OpenAlex author A5100425879 Funded by National Cancer Institute, NIH › NIH, PRIMED · active “an NIH-funded consortium aiming to develop and evaluate methods to improve the use of PRS” National Cancer Institute, K99/R00 Pathway to Independence Award “During his postdoctoral training, he received the K99/R00 Pathway to Independence Award from the National Cancer Institute.” Source: lab pages 9 platforms and techniques › Analyzes 23andMe, UK Biobank, All of Us, NIH Data Commons Techniques genetic association testing, Mendelian randomization, multi-ancestry association testing, multi-ancestry polygenic risk scores, heritability estimation Source: lab pages No openings posted	Talk Thu Oct 22 11:00 am RICEx integrates common and rare variants from summary statistics for multi-trait, multi-ancestry risk prediction Polygenic Risk Score: From Modeling to Clinical Decision Collaborators: University of North Carolina at Chapel Hill Genome-wide association studyPolygenic risk scoreComplex diseasesComplex traits
Trans-Divisional Research Program Works in cancer genetics and population genetics.	Talk Fri Oct 23 1:30 pm The largest multi-ancestry fine-mapping in over 2 million participants improves credible set resolution and enrichment in breast regulatory elements MAMO: Multi-Ancestry-Aware Multi-Omics Analysis for Complex Diseases Collaborators: Division of Cancer Epidemiology and Genetics CancerEtiologyGenetic epidemiologyGenome-wide association study

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