ASHG 2026 · Hospital & health system
Mayo Clinic at ASHG 2026
Rochester, Minnesota
Mayo Clinic at ASHG 2026 in Montréal: 15 presentations (13 posters, 1 lightning talk, 1 plenary); 11 research groups.
15
presentations on the program
11
research groups identified
2
sessions invited to or moderated
1
Reviewers’ Choice abstracts
| Organization | ASHG 2026 Attendance |
|---|---|
Mayo Clinic Rochester, Minnesota | 9 PIs · 3 Faculty · 2 Postdocs · 1 Clinician |
Division of Computational Biologymayo.edu/research/departments-divisions/computational-biology/overview Analyzes ATAC-seq, RNA-seq, proteomic, metabolomic and whole-slide image data with statistical genetics and machine learning. Supports Mayo Clinic biomedical discovery, translational research and patient care.
| Talk Wed Oct 21 1:47 pm Dissecting obesity heterogeneity using cross-trait PRS and data-driven clustering for precision risk prediction Artificial intelligenceComplex diseasesPolygenic risk scoreRisk assessment Poster Wed Oct 21 2:30 pm Subtype-specific comorbidity risks and genetic etiologies in obesity Complex diseasesElectronic health recordsGenetic variationObesity Poster Fri Oct 23 2:30 pm ★ Reviewers’ Choice Dissecting Obesity Heterogeneity Using Cross-Trait PRS and Data-Driven Clustering for Precision Risk PredictionArtificial intelligenceComplex diseasesMachine learningPolygenic risk score Poster Fri Oct 23 2:30 pm Joint effects of polygenic risk scores and family history information on absolute risk prediction with a method for incomplete family history Polygenic risk scoreFamily historyRisk assessmentLarge-scale biobanks |
Abyzov Labmayo.edu/research/labs/somatic-mutations-development-aging/overview Analyzes whole-genome sequencing, single-cell sequencing, ChIP-seq, ATAC-seq, Hi-C and RNA-seq data for somatic variants and mosaicism. Studies human development, neurodevelopmental disorders and cancer.
| Poster Wed Oct 21 2:30 pm Accurate detection of sub-1% frequency somatic mutations by whole genome sequencing Somatic variantsMosaicismSingle-cellExome/genome sequencing Plenary Thu Oct 22 2:49 pm Charting mutation heterogeneity across human tissues: Early results from SMaHT GenomicsLaboratory genetics and genomicsMosaicismMutation detection |
Translational Omics Programmayo.edu/research/centers-programs/center-individualized-medicine/research/pillars-programs/translational-omics Interprets RNA sequencing, genome sequencing and methylation sequencing alongside functional studies. Focuses on rare and undiagnosed genetic diseases, populational genomics and preventive genomic screening.
| Session Tue Oct 20 10:00 am Poster Thu Oct 22 4:15 pm Functional Insights into a Novel SGCE Variant in Adult-Onset Dystonia Variant interpretationMendelian disorderNeurogeneticsMolecular pathophysiology |
Division of Hematopathologymayoclinic.org/departments-centers/laboratory-medicine-pathology/overview/specialty-groups/hematopathology/overview Runs multicolor flow cytometry, RNA/DNA molecular testing, microscopy, cytochemical stains and coagulation assays. Diagnoses hematologic diseases for Mayo physicians and Mayo Clinic Laboratories clients.
| Poster Thu Oct 22 4:15 pm Validation of an artificial intelligence (AI) model empowered workflow for enumeration FISH probes for myelodysplastic neoplasms (MDS) Artificial intelligenceCancer cytogeneticsFISHLaboratory genetics and genomics |
PRIMED Consortium Data Sharing Working Groupprimedconsortium.org/working-group/data-sharing Develops data-sharing policies for genotype, phenotype and summary-statistics data on AnVIL, dbGaP and PGS Catalog. Supports PRS development and validation across PRIMED study sites.
| Poster Wed Oct 21 2:30 pm Impact of genetic risk factors on coronary heart disease risk across the age spectrum in three major race/ethnicity groups in the United States Polygenic risk scoreFamily historyCardiovascular systemRisk assessment |
Statistical Genetics and Genetic Epidemiology Laboratorymayo.edu/research/labs/statistical-genetics-genetic-epidemiology/overview Develops statistical methods and software for DNA and RNA sequence variation, proteomics, metabolomics and genetic data. Applies them to disease prediction and genetic epidemiology.
| Poster Thu Oct 22 4:15 pm Federated Elastic Net Modeling from Summary Statistics Enables Privacy-Preserving Integration Across Multi-Biobank Genetic Studies Statistical geneticsComplex diseasesComplex traitsPolygenic risk score |
Experimental Pathology and Laboratory Medicinemayo.edu/research/departments-divisions/department-laboratory-medicine-pathology/division-experimental-pathology-laboratory-medicine/faculty Provides ChIP-seq, ATAC-seq, scATAC-seq and scMultiome services alongside molecular, cellular, genetic and epidemiological research. Targets cancer diagnosis, treatment and prevention.
| Moderator Sat Oct 24 9:45 am |
Clinical Genomics Sequencing Laboratory Works in computational genetics. | Poster Thu Oct 22 4:15 pm Probing Large Language Model Behavior Using Patient-style Queries on Hematologic Genetic Variants Artificial intelligencePublic healthGenetic counselingPrecision medicine |
Hereditary oncology subdiscipline Works in cancer genetics and clinical genetics. | Poster Fri Oct 23 2:30 pm Characterization of PMS2CL deletions and PMS2/PMS2CL hybrid alleles that confound germline PMS2 testing for Lynch syndrome Cancer syndromesCopy number/structural variationDiagnosticsRare variants |
Clinical Genomics Laboratory Research group. | |
Lomberk Research Laboratory Research group. | |
| 3 more presenters — research group not yet identified | |
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