Jackson Laboratory at ASHG 2026

Oct 20–24, 2026 Montréal, Canada ~7.5k attendees Website

Jackson Laboratory brings 5 presentations from 4 research groups to ASHG 2026 in Montréal. Its program centres on functional regulatory variation, genomic technologies, and disease genetics at this meeting. Tewhey Lab presents functional tests of autoimmune risk variants in human T cells, Advanced Precision Medicine Laboratory presents near telomere-to-telomere mouse genome assemblies, and Chesler Lab links substance-use-disorder genetics across mice and humans.

Organization	ASHG 2026 Attendance
Jackson Laboratory Bar Harbor, Maine	2 Staff Scientists · 1 PI · 1 Postdoc · 1 PhD Student
Tewhey Labjax.org/research-and-faculty/research-labs/the-tewhey-lab Wet + dry lab~7 people Develops MPRA, CRISPR screens and mouse models to study non-coding regulatory variation. Applies them to type 2 diabetes, colorectal cancer and autoimmune diseases. 18 papers since 2024 › Machine-guided design of cell-type-targeting cis-regulatory elements Nature, 2024 CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods Genome biology, 2024 Multicenter integrated analysis of noncoding CRISPRi screens Nature Methods, 2024 Source: OpenAlex author A5079877718 Funded by NIH/NHGRI › NIH/NHGRI, ENCODE Functional Characterization Center · active “as part of a multi-year NIH/NHGRI ENCODE Functional Characterization Center study” Source: lab pages 11 platforms and techniques › Runs Massively parallel reporter assays (MPRA), CRISPR-based screening, MPRAduo, HCR-FlowFISH, CODA Techniques Mouse models, CRISPR interference (CRISPRi), Generative deep-learning models, Multiplex genomic modifications, Human T-cell engineering, Zebrafish and mouse validation models Source: lab pages No openings posted	Poster Thu Oct 22 4:15 pm Part of Omics Technologies Poster Thursday Session Improving lentiviral massively parallel reporter assays by preventing transgene silencing Exhibit & Poster Hall · Board 8192T Collaborators: Tufts University Massively parallel sequencingGene regulationRegulation of transcriptionStem cell Talk Sat Oct 24 8:30 am Part of From Autoimmune Risk Variants to Cell States and Target Genes: Integrative Genetic Dissection of Immune-Mediated Disease Direct functional characterization of autoimmune risk variants reveals cell state-specific allelic effects in human CD4+ T cells Room 516BC/Level 5 Autoimmune disorderGene regulationMassively parallel sequencingSingle-cell
Advanced Precision Medicine Laboratoryjax.org/clinical-genomics/advanced-precision-medicine-lab Wet + dry lab Runs Illumina and PacBio sequencing, whole-genome sequencing, Infinium MethylationEPIC Array, ddPCR and qPCR. Supports cancer and rare-disease diagnosis. 18 papers since 2024 › Unlocking the regulatory code of RNA: launching the Human RNome Project Genome biology, 2025 Phenotypic Expansion of Knobloch Syndrome Type 2 in an Individual With a De Novo PAK2 Variant American Journal of Medical Genetics Part A, 2025 Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor Cell Host & Microbe, 2024 Source: OpenAlex author A5030017379 Funded by National Human Genome Research Institute › National Human Genome Research Institute, Technology Development Coordinating Center · active “He also leads the NHGRI-funded Technology Development Coordinating Center.” Source: lab pages 13 platforms and techniques › Runs Illumina sequencers, PacBio sequencers, Whole Genome Sequencing, JAX SomaticSeq RUO, Infinium Global Diversity Array, Infinium MethylationEPIC Array, ddPCR, qPCR Techniques Methylation profiling, Bisulfite conversion, H&E staining, Tertiary analysis, Machine-learning analysis Source: lab pages No openings posted	Poster Wed Oct 21 2:30 pm Part of Genetic, Genomic, and Epigenomic Resources and Databases Poster Wednesday Session The generation of near telomere-to-telomere genome assemblies for DBA/2J and 129S1/SvImJ Exhibit & Poster Hall · Board 4050W Collaborators: The Jackson Laboratory for Genomic Medicine, University of Connecticut GenomicsLong-read sequencingVariant calling
Beck Labjax.org/research-and-faculty/research-labs/the-beck-lab Wet + dry lab~3 people Studies structural variation using long-read DNA sequencing, long-read mRNA sequencing and PAV variant-discovery software. Applies computational and bench methods to repetitive DNA and cancer. 13 papers since 2024 › Complete sequencing of ape genomes Nature, 2025 Complex genetic variation in nearly complete human genomes Nature, 2025 Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation Science, 2024 Source: OpenAlex author A5085413565 9 platforms and techniques › Works with Pacific Biosciences long-read mRNA sequencing, PAV, Long-read sequencing Techniques Complex structural variant discovery, Genome assembly, Transposable element variant analysis, Diverse inbred mouse strains, Embryonic stem cells, Molecular biological techniques Source: lab pages No funding stated · No openings posted	Talk Sat Oct 24 10:15 am Part of Move Over SNPs: Structural Variants, Repeat Expansions, and More PAV 3: Comprehensive variant discovery across a range of variant types and sizes Room 511/Level 5 Collaborators: University of Washington, University of Southern California +5 more BioinformaticsComputational toolsCopy number/structural variationLong-read sequencing
Chesler Labjax.org/research-and-faculty/research-labs/the-chesler-lab Wet + dry lab Integrates mouse genetic, genomic and phenomic data with human behavioral-disorder data using GeneWeaver and genetic reference populations. Targets addiction and complex-behavior genetics. 30 papers since 2024 › GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis Genome Research, 2024 An emerging multi-omic understanding of the genetics of opioid addiction Journal of Clinical Investigation, 2024 Improving the predictive power of mouse models Nature Biotechnology, 2024 Source: OpenAlex author A5022843316 Funded by NIDA › NIDA, Growing the Genetics of Addiction Workforce with Faculty-Student Research Experiences · active “is offering a NIDA-funded research and training program” Source: lab pages 9 platforms and techniques › Analyzes GeneWeaver, Mouse Phenome Database Techniques Quantitative genetics, Bioinformatics, Cross-species genomic data integration, Collaborative Cross mouse populations, Diversity Outbred mouse populations, QTL mapping, Transcriptome profiling Source: lab pages No openings posted	Symposium Fri Oct 23 9:05 am Part of Translational Models for Substance Use Disorders Genetic studies of substance use disorders reveal convergent gene regulatory mechanisms in mice and humans Room 516BC/Level 5

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