Uses genome and exome sequencing, ChIP-seq, RNA-seq, single-cell RNA-seq and integrated genomic data. Studies gene-regulatory networks in cancer and human disease.
62 papers since 2024
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Gene regulatory networks reveal sex difference in lung adenocarcinoma
Biology of Sex Differences, 2024
Biologically informed NeuralODEs for genome-wide regulatory dynamics
Genome biology, 2024
Sex-Biased Regulation of Extracellular Matrix Genes in Chronic Obstructive Pulmonary Disease
American Journal of Respiratory Cell and Molecular Biology, 2024
Develops computational tools for metabolomics, DNA methylation and other multi-omics data. Uses longitudinal cohorts to model disease risk and intervention benefit.
105 papers since 2024
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Optimal dietary patterns for healthy aging
Nature Medicine, 2025
Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk
Nature Metabolism, 2024
Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial
Develops statistical and machine-learning methods for whole-genome sequencing, multi-omics, biobank and phenotype data. Uses them for complex-disease risk, causal inference and functional variant analysis.
69 papers since 2024
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Accelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality
Nature Cardiovascular Research, 2024
Deciphering the impact of genomic variation on function
Nature, 2024
Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height
Funded by National Cancer Institute (NCI), National Heart, Lung, and Blood Institute +2 more
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National Cancer Institute (NCI), Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research · 2015-2029
“Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research (2015-2029) – the National Cancer Institute (NCI)”
National Heart, Lung, and Blood Institute, Statistical Methods for Integrative Analysis of Large-Scale Multi-Ethnic Whole Genome Sequencing Studies and Biobanks of Common Diseases · active
“Statistical Methods for Integrative Analysis of Large-Scale Multi-Ethnic Whole Genome Sequencing Studies and Biobanks of Common Diseases – the National Heart, Lung, and Blood Institute”
National Human Genome Research Institute (NHGRI), Impact of Genomic Variation on Function (IGVF) · active
“Impact of Genomic Variation on Function (IGVF) – Program of the National Human Genome Research Institute (NHGRI)”