ASHG 2026 · Hospital & health system

Children's Mercy Hospital at ASHG 2026

Kansas City, Missouri

Children's Mercy Hospital at ASHG 2026 in Montréal: 8 presentations (7 posters, 1 platform talk); 7 research groups.

8
presentations on the program
7
research groups identified

Explore everyone at ASHG 2026 →

OrganizationASHG 2026 Attendance
Children's Mercy Hospital
Kansas City, Missouri
4 Clinicians · 3 Staff Scientists · 1 PI
Genomic Medicine Centerchildrensmercy.org/childrens-mercy-research-institute/research-areas/genomic-medicine-center
Wet + dry lab~8 people
Runs HiFi, 5-base, whole-genome and exome sequencing; analyzes methylation and expressed RNA. GA4K supports pediatric rare-disease diagnosis and treatment discovery.
65 papers since 2024
Rapid and scalable personalized ASO screening in patient-derived organoids
Nature, 2025
Characterization and visualization of tandem repeats at genome scale
Nature Biotechnology, 2024
DNA mismatch and damage patterns revealed by single-molecule sequencing
Nature, 2024
Source: OpenAlex author A5028053766
Funded by NIH, NIH/NIAID
NIH, Research Project Grant (R01) · July 18, 2024-April 30, 2029
The NIH's standard multi-year research project grant.
“Research Project Grant (R01) from the National Institute of Health”
NIH/NIAID, R21 award · July 1, 2025-June 30, 2027
“received a $433,175 R21 award from the National Institutes of Health – National Institute of Allergy and Infectious Diseases”
Source: lab pages
15 platforms and techniques
Works with
NovaSeq 6000, Next Seq 2000, Pacific Biosciences Sequel IIs, 10X Chromium System, Fluidigm C1, HiFi sequencing, 5-base sequencing, DNAnexus genomics cloud platform
Techniques
Whole genome sequencing, Whole exome sequencing, WGBS, Bulk and single-cell RNA analysis, Human assembly, Patient-derived cell models, Single-nucleus epigenome analysis
Source: lab pages
Currently hiring
“we are always interested in recruiting new lab members who work in computational and genomics research”
Source: lab positions page
Poster
Fri Oct 23
2:30 pm
Direct-to-provider genomic testing model to help reach more rare disease patients
Health Services Research and Implementation Science
Collaborators: Salina Regional Health Center, University of Kansas
DiagnosticsEducationExome/genome sequencingGenetic testing
Poster
Fri Oct 23
2:30 pm
High-Resolution Genomics Analysis of Chromosome 22q11.2 Deletion Syndrome
Omics Technologies
BioinformaticsEpigeneticsImmune systemMulti-omics
Division of Clinical Geneticschildrensmercy.org/departments-and-clinics/genetics-clinic/genetics-clinic-team
Wet lab~19 people
Provides biochemical testing, chromosome analysis, microarray comparative genomic hybridization and molecular DNA studies. Evaluates inherited conditions, chromosome disorders and genetic birth defects in children.
7 platforms and techniques
Runs
Biochemical testing, Chromosome analysis, Microarray comparative genomic hybridization, Molecular DNA studies
Techniques
Karyotyping, Pedigree construction, Pediatric and prenatal genetic counseling
Source: lab pages
No funding stated · No openings posted
Poster
Thu Oct 22
4:15 pm
Germline RRAS Pathogenic Variant in Neonate with Clinical Features of Noonan Syndrome
Mendelian Phenotypes
Rare variantsPhenotypeGenotype-phenotype correlationsGenetic testing
Genetics Clinicchildrensmercy.org/departments-and-clinics/genetics-clinic/genetics-clinic-team
Wet lab~19 people
Provides biochemical testing, chromosome analysis, microarray comparative genomic hybridization and molecular DNA studies. Evaluates inherited conditions, chromosome disorders and genetic birth defects in children.
7 platforms and techniques
Runs
Biochemical testing, Chromosome analysis, Microarray comparative genomic hybridization, Molecular DNA studies
Techniques
Karyotyping, Pedigree construction, Pediatric and prenatal genetic counseling
Source: lab pages
No funding stated · No openings posted
Poster
Fri Oct 23
2:30 pm
Expanding the reported clinical severity of a recurrent variant in FLNC
Mendelian Phenotypes
Cardiovascular systemCharacterization of syndromesClinical geneticsClinical testing
Polyposis Centerchildrensmercy.org/departments-and-clinics/gastroenterology/gastrointestinal-polyposis
Wet lab~3 people
Uses genetic testing, double-balloon enteroscopy and video capsule endoscopy for pediatric hereditary polyposis. Works with the Genome Center on cancer-risk and treatment questions.
7 platforms and techniques
Works with
Double Balloon Enteroscopy (DBE), Video capsule endoscopy, Exome sequencing
Techniques
Endoscopic resection, Genetic testing, Patient-specific polyp replicas, Genotype-phenotype correlation
Source: lab pages
No funding stated · No openings posted
Poster
Thu Oct 22
4:15 pm
Discovery of gastric adenocarcinoma in a 17 year-old patient with a germline pathogenic variant in CTNNA1
Genetic Counseling, ELSI, and Education
Collaborators: University of Missouri
Genetic counselingGastrointestinal systemCancerCancer syndromes
Smail Lab at Children's Mercy Hospitalsites.google.com/view/smail-lab/home
Dry lab~4 people
Uses PacBio HiFi long-read WGS, short- and long-read genomic data and single-cell RNA-sequencing. Maps rare DNA variation and uncovers pathogenic variants in undiagnosed rare diseases.
9 papers since 2024
RNA Sequencing in Disease Diagnosis
Annual Review of Genomics and Human Genetics, 2024
Complex trait associations in rare diseases and impacts on Mendelian variant interpretation
Nature Communications, 2024
Genomic insights into pediatric intestinal inflammatory and eosinophilic disorders using single-cell RNA-sequencing
Frontiers in Immunology, 2024
Source: OpenAlex author A5080231471
Funded by NIGMS, NHGRI +1 more
NIGMS, R35 MIRA grant · 2022
“NoA received from NIGMS for our R35 MIRA grant on non-Mendelian pediatric rare disease genomics.”
NHGRI, R21 grant · 2022
“NoA received from NHGRI for our R21 grant on novel approaches for relating genetic variation to function and disease.”
Marion Merrell Dow/Ed Connolly, Research Scholar · 2021
“Craig is selected as the 2021 Marion Merrell Dow/Ed Connolly Research Scholar.”
Source: lab pages
12 platforms and techniques
Analyzes
PacBio HiFi long-read WGS, short-read genomic data, long-read genomic data, single-cell RNA-sequencing, blood transcriptome sequencing, single-cell transcriptomics
Techniques
polygenic risk prediction, rare variant interpretation, iPSC cardiac organoids, pluripotent cell transcriptomics, structural variant analysis, multiomics
Source: lab pages
Currently hiring
“We have multiple openings across career stages.”
Source: lab positions page
Poster
Fri Oct 23
2:30 pm
Population-Specific Structural Variant Landscape in a Puerto Rican Rare Disease Cohort
Evolutionary and Population Genetics
Collaborators: University of Missouri–Kansas City, University of Puerto Rico, Medical Sciences Campus
Population geneticsLong-read sequencingGenetic variationCopy number/structural variation
Younger Laboratoryyoungerlab.org
Wet lab~4 people
Generates patient-derived iPSCs and organoids for high-throughput phenotypic and patient-specific drug screening. Supports clinical implementation of patient-specific drug-response prediction.
4 papers since 2024
Rapid and scalable personalized ASO screening in patient-derived organoids
Nature, 2025
Supplementary Data from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Preprint or unlisted venue, 2025
Supplementary Figures from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Preprint or unlisted venue, 2025
Source: OpenAlex author A5041456482
13 platforms and techniques
Runs
iPSC reprogramming, Organoid generation, High-throughput phenotypic screening, Patient-specific drug screening, Pooled CRISPR screens, Personalized ASO screening
Techniques
iPSC reprogramming, Organoid generation, High-throughput organoid phenotyping, Mammalian cell culture, Stem cell models, Pooled CRISPR screens, ASO screening
Source: lab pages
Currently hiring
“The Younger Lab is actively searching for highly motivated PhD-level scientists”
Source: lab positions page
No funding stated
Talk
Fri Oct 23
1:30 pm
Rapid individualized drug repurposing for the treatment of rare genetic diseases using patient-derived organoids
Modeling Genetic Disorders with Organoids
Precision medicineTranslational studies and preclinical trialsEpilepsyStem cell
Laboratory of Immunogenomics (Bradley Lab)
Works in clinical genetics.
Poster
Thu Oct 22
4:15 pm
Unraveling Clinical Variability in Children with Down Syndrome: A Single-Immune Cell Genomics Approach
Omics Technologies
AneuploidyAutoimmune disorderImmune systemMulti-omics

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